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Overview

Uniprot IDF1S762
Protein NameSterol carrier protein 2
Gene NamePODN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
406 FKANLVFKEIEKRLE
422 EGEQFVKKIGGIFAF
432 GIFAFKVKDGPEGRE
459 AVLPNSDKKADCTIT
505 NLQLQPSKAKL****

Function

Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs

Protein Sequence

10 MENLYLLFIY 20 FFVFLFFSGP 30 HPRHMEVPRL 40 GCHVTLQLPN 50 YHVAYIILFF 60 YVGDSTCGQR 70 SIYHSLGLTG 80 IPIINVNNNC 90 STGSTALFMA 100 RQLIQGGLAD 110 CVLFANRTNP 120 IDKHVEVMIN 130 KYGLSPHPFA 140 AQLFGHAGIE 150 HMEKYGTKPE 160 HFAKIGWKNH 170 KHAVNNPYSQ 180 FQKEYSLDEV 190 MSSQRIFEYL 200 TILQCCPTSD 210 GAAAAVLASE 220 VFVQKNGLKS 230 KAVEIVAQEM 240 ITDLPSSFEE 250 NSMIKVVGFD 260 MSKEAARKCY 270 EKSGLRPSDI 280 DVIELHDCFS 290 SNELFTYEAL 300 GLCPEGQGGK 310 LVDDGDNTYG 320 GKWVINPSGG 330 LIAKGHPLGA 340 TGLAQCAELC 350 WQLRGEAGKR 360 QVPGAKVALQ 370 HNLGLGGAAV 380 VTLYRMGFPE 390 AARSPQVEAV 400 PTSSTLDGFK 410 ANLVFKEIEK 420 RLEEEGEQFV 430 KKIGGIFAFK 440 VKDGPEGREA 450 TWVVDVKNGK 460 GAVLPNSDKK 470 ADCTITMSDS 480 DLVALMMAFF 490 QGKLKVLGNM 500 GLAMKLQNLQ LQPSKAKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0003988 acetyl-CoA C-acyltransferase activity
Molecular Function GO:0050633 acetyl-CoA C-myristoyltransferase activity
Molecular Function GO:0008289 lipid binding
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0006869 lipid transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.