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Overview

Uniprot IDF1S764
Protein NameCarnitine O-palmitoyltransferase 2, mitochondrial
Gene NameCPT2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
189 RSDTATFKRLIRLVP
510 RPASVFTKRCSEAFV

Function

Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters

Protein Sequence

10 MMARLLLRAW 20 PRDLAVGLAA 30 PCRTLSAGFE 40 PGQYLQRSIV 50 PTMHFQDSLP 60 RLPIPKLEDT 70 MRRYLSAQKP 80 LLDDGQFRKT 90 EELCKNFENG 100 IGKKLHEQLV 110 AQDKQNKHTS 120 YISGPWFDMY 130 LTARNPIVLN 140 FNPFMAFHPD 150 PKSEYNDQLT 160 RATNLTVSAL 170 RFLKALRAGL 180 LEPEVFHLNP 190 ARSDTATFKR 200 LIRLVPSALS 210 WYGAYLVKAY 220 PLDMSQYFRL 230 FNSTRLPRPR 240 RDELFTDDKA 250 RHLLVLRKGH 260 FYVFDVLDQD 270 GKIVSASEIQ 280 AHLKYILSDR 290 SLAPEFPLAY 300 LTSEDRDIWA 310 GLRQKLVQGG 320 NEETLRRVDA 330 AVFCLCLDDF 340 PVKDLIHLSH 350 SMLHGDGTNR 360 WFDKSFNLIL 370 AEDGTAAVHF 380 EHAWGDGVAV 390 LRFLNEVFKD 400 STQAPAVTPQ 410 SPPARTDSSR 420 AVQKLSFKLD 430 DAVKAGISAA 440 KAKFDATVKT 450 LTIDCIQFQR 460 GGKEFLKGQK 470 VSPDSVAQLA 480 FQMAFLRQYG 490 QTVATYESCS 500 TAAFKHGRTE 510 TIRPASVFTK 520 RCSEAFVREP 530 SKHSAAALRQ 540 MVAECSEYHN 550 QLTREAAMGQ 560 GFDRHLFALR 570 NLAKAKGIAL 580 PELYLDPAYK 590 QINHNILSTS 600 TLSSPAVNLG 610 GFAPVVPDGF 620 GIGSQVLWIP 630 WLERRHSCGC 640 RCTETHAALI QEP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0004095 carnitine O-palmitoyltransferase activity
Biological Process GO:0006635 fatty acid beta-oxidation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.