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Overview

Uniprot IDF1S7C4
Protein NameEndoplasmic reticulum transmembrane helix translocase
Gene NameATP13A1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
698 CPLKADSKAVIREIQ

Function

Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains

Protein Sequence

10 MAAAVGNAVP 20 CGARHCGARP 30 AGQPKPKPQP 40 RTVLAAGPAL 50 IASGDELVAA 60 VWPYRRLALL 70 RRLTVLPFAG 80 LLYPAWLGAA 90 AAGCWGWGSS 100 WAQIPEAALL 110 VLATICLAHA 120 LTVLSGHWSV 130 HAHCALTCTP 140 GEDGQEVLSF 150 EFQKIKYSYD 160 ALEKKRFLPV 170 AFPVGNAFSY 180 YQSNRGFQED 190 SEIRAAEKKF 200 GSNKAEMVVP 210 DFSELFKERA 220 TAPFFVFQVF 230 CVGLWCLDEY 240 WYYSVFTLSM 250 LVAFEASLVQ 260 QQMRNMSEIR 270 KMGNKPHMIQ 280 VYRSRKWRPI 290 ASDEVVPGDI 300 VSIGRSPQEN 310 LVPCDVLLLR 320 GRCIVDEAML 330 TGESVPQMKE 340 PIEDLSPNRV 350 LDLQADSRLH 360 VIFGGTKVVQ 370 HIPPQKATTG 380 LKPVDNGCVA 390 FVLRTGFNTS 400 QGKLLRTILF 410 GVKRVTANNL 420 ETFIFILFLL 430 VFAIAAAAYV 440 WIEGTKDPSR 450 NRYKLFLECT 460 LILTSVVPPE 470 LPIELSLAVN 480 TSLIALAKLY 490 MYCTEPFRIP 500 FAGKVEVCCF 510 DKTGTLTSDS 520 LVVRGVAGLR 530 DGKEVTPVSN 540 IPIETHRALA 550 SCHSLMQLDD 560 GTLVGDPLEK 570 AMLTAVDWTL 580 TKDEKVFPRS 590 IKTQGLKIHQ 600 RFHFASALKR 610 MSVLASYEKL 620 GSTDLCYIAA 630 VKGAPETLHS 640 MFAQCPPDYH 650 HIHTEISREG 660 ARVLALGYKE 670 LGHLTHQQAR 680 EVKREALECN 690 LKFVGFIVVS 700 CPLKADSKAV 710 IREIQNASHR 720 VVMITGDNPL 730 TACHVAQELH 740 FIEKAHTLIL 750 QPPTEKGQPC 760 EWRSIDGSII 770 LPLAPGSPKA 780 LALEHALCLT 790 GDGLAHLQAE 800 DPQLLLRLIP 810 YVQVFARVAP 820 KQKEFVITSL 830 KELGYVTLMC 840 GDGTNDVGAL 850 KHADVGVALL 860 ANAPERVIER 870 RRRPRDSPIL 880 SNSGVRTTSR 890 AAKQRSGLPP 900 PEEQLASQRD 910 RLSQVLRDLE 920 DESTPIVKLG 930 DASIAAPFTS 940 KLSSIQCICH 950 VIKQGRCTLV 960 TTLQMFKILA 970 LNALILAYSQ 980 SVLYLEGVKF 990 SDFQATLQGL 1000 LLAGCFLFIS 1010 RSKPLKTLSR 1020 ERPLPNIFNL 1030 YTILTVMLQF 1040 CVHFVSLVYL 1050 YSEAQARSPE 1060 KQEQFVDLYK 1070 EFEPSLVNST 1080 VYIMAMAMQM 1090 ATFAINYKGP 1100 PFMESLPENR 1110 PLVWSLAVSL 1120 FAIVGLLLGS 1130 SPDFNSQFGL 1140 VDIPVEFKLV 1150 IAQVLLLDFC 1160 LALLADRVLQ 1170 FFLGTPKLKV PS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140567 membrane protein dislocase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0140358 P-type transmembrane transporter activity
Biological Process GO:0015031 protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.