Overview
| Uniprot ID | F1S7E0 |
|---|
| Protein Name | Coatomer subunit epsilon |
|---|
| Gene Name | COPE |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 257 |
NRYLSQLKDAHRTHP |
| 272 |
FIKEYHAKENDFDRL |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors
Protein Sequence
10
MAPPAPGPAS
20
GGSGEVDELF
30
DVKNAFYIGS
40
YQQCINEAQR
50
VKRKFGVVLD
60
EIKPSSAPEL
70
QAIRMFAEYL
80
ASDSRRDAIV
90
AELDREMSRS
100
VDVTNTTFLL
110
MAASIYFHDQ
120
NPDAALRTLH
130
QGDSLECMAM
140
TVQILLKLDR
150
LDLARKELKK
160
MQDQDEDATL
170
TQLATAWVNL
180
AVGGEKLQDA
190
YYIFQEMADK
200
CSSTLLLLNG
210
QAACHMAQGR
220
WEAAEGVLQE
230
ALDKDSSHPE
240
TLINLIVLSQ
250
HLGKPPEVTN
260
RYLSQLKDAH
270
RTHPFIKEYH
280
AKENDFDRLV
LQYAPSA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030663 |
COPI-coated vesicle membrane |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.