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Overview

Uniprot ID	F1S7K1
Protein Name	E3 ubiquitin-protein ligase UHRF
Gene Name	UHRF1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
24	NSLSRLTKVENLRRR
327	ACRLCGGKQDPDKQL
503	AEQSCDQKLTNTNRA
563	NRYDGIYKVVRYWPE

Function

Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications

Protein Sequence

10 MWIQVRTMDG 20 KVAHTVNSLS 30 RLTKVENLRR 40 RIQEVFHVEP 50 GLQRLFYRGK 60 QMEDGHTLFD 70 YDVRLNDTIQ 80 LLVRQSPISS 90 SSSSSKERDS 100 ELSDTDSGCC 110 LGQSESDKSS 120 NSGEAANEPE 130 VKADEDTWDE 140 TELGLYKAGE 150 YVDARDTNMG 160 AWFEAQVIRV 170 TKKTVAQDRP 180 CSSSSSSSST 190 LEDDVIYHVK 200 YEDYPENGVV 210 QLSSRDVRAR 220 ARQILKWHEL 230 EVGQVVMLNY 240 NTDSPKDRGF 250 WYDAEILRKR 260 ETRTARELHA 270 NVRIGDDSLN 280 DCRIIFVDEV 290 FKIERPGEGS 300 PLVETPVRRK 310 SGPTCKHCKD 320 NPRKLCRMCA 330 CRLCGGKQDP 340 DKQLMCDECD 350 MAFHMYCLCP 360 PLSSVPSEAE 370 WYCPECRIDS 380 SEVVQAGEKL 390 KESKKKAKMA 400 SATSSSQRDW 410 GKGMACVGRT 420 KECTIVPSNH 430 YGPIPGIPVG 440 TMWRFRVQVS 450 ESGVHRPHVA 460 GIHGRSNDGA 470 YSLVLAGGYE 480 DDVDHGNSFT 490 YTGSGGRDLS 500 GNKRTAEQSC 510 DQKLTNTNRA 520 LALNCFAPIN 530 DRKGAEAKDW 540 RSGKPVRVVR 550 NVKGRKHSKY 560 APVEGNRYDG 570 IYKVVRYWPE 580 KGKSGFLVWR 590 FLLRRDDVEP 600 GPWTKEGKDR 610 IKKLGLTMQY 620 PEGYLEALAK 630 KEKEKENKNS 640 KRAAVEEEEE 650 EGREDFETPR 660 KGKRKSQAAG 670 GDGPSRGAPK 680 KTKVEPYSLT 690 AQQSSLIKED 700 KSNTKLWTEI 710 LKSLKDGPKF 720 LSKVEETFQC 730 ICCQELVFRP 740 ITTVCQHNVC 750 KDCLDRSFKA 760 QVFSCPACRY 770 NLGRHSTMQV 780 NQPLQAVLSQ LFPGYGNGR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000792	heterochromatin
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0042393	histone binding
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0044027	negative regulation of gene expression via chromosomal CpG island methylation
Biological Process	GO:0016567	protein ubiquitination
Biological Process	GO:0006950	response to stress

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.