Search Results

Overview

Uniprot ID	F1S7V9
Protein Name	Monofunctional C1-tetrahydrofolate synthase, mitochondrial
Gene Name	MTHFD1L
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
311	RWKLHCLKLQPLSPV
331	ISRAQTPKAVDVLAK
493	NGIREFSKIQLARLK

Function

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2

Protein Sequence

10 PLSLSHIFNL 20 FLGRNLQPLG 30 KGCQSPDQGL 40 NPGGREVIQN 50 SKEVLSLLQE 60 KNPAFKPVLA 70 VIQAGEDNLM 80 QEINQKLAEE 90 AGLNITHICL 100 PADSSEDEII 110 DEILKINEDS 120 RVHGLALQIS 130 ETSFSSKILH 140 ALKPEKDVDG 150 VTDVNLGKLV 160 RGDAHDCFVS 170 PVARAVIELL 180 EKSGVNLDGR 190 KILVIGAHGS 200 LEATLQCLFQ 210 RKGSMTMSSQ 220 WKAPQLQSKL 230 HEADVVIFGS 240 PKPEEVPLSW 250 IQQGTAVLNC 260 SHDFLSGKWL 270 QIGSPGIHGH 280 SLIAEDVSLL 290 AAALRIQNMV 300 GSGRRWLREQ 310 QYRRWKLHCL 320 KLQPLSPVPS 330 DIEISRAQTP 340 KAVDVLAKEI 350 GLLEDEIEIY 360 GRSKAKVRLS 370 LLERLKDQAD 380 GKYVLVAGIT 390 PTPLGEGKST 400 VTIGLVQAMT 410 AHLNVNSFAC 420 LRQPSQGPTF 430 GVKGGAAGGG 440 YAQVIPMEEF 450 NLHLTGDIHA 460 ITAANNLLAA 470 AIDTRILHEN 480 TQTDKALYNR 490 LVPSVNGIRE 500 FSKIQLARLK 510 KLGINKTDPS 520 ALTEDEMRKF 530 ARLDIDPATI 540 TWQRVLDTND 550 RFLRKITLGR 560 GTQRKAQFDI 570 AVASEIMAVL 580 ALTDSLKDMK 590 ERLGRMVVAS 600 DKNGQPVTAD 610 DLGVTGALTV 620 LMKDAIKPNL 630 MQTLEGTPVF 640 VHAGPFANIA 650 HGNSSVLADK 660 IALKLVGEEG 670 FVVTEAGFGA 680 DIGMEKFFNI 690 KCRASGLVPN 700 VVVLVATVRA 710 LKMHGGGPSV 720 TAGVPLKKEY 730 TEENLQLVAD 740 GCCNLKKQIQ 750 IAQLFGVPVV 760 VALNVFKTDT 770 RAEIDLVCEL 780 AKQAGAFDAV 790 PCYHWSVGGK 800 GSVDLAWAVS 810 EAAHKGSRFQ 820 FLYDVQLPIV 830 EKIRTIAQAV 840 YGARDIELSS 850 EAQSKIDRYT 860 EQGFGNLPIC 870 MAKTHLSLSH 880 QPDKKGVPKD 890 FILPITDVRA 900 SIGAGFIYPL 910 VGTMSTMPGL 920 PTRPCFYDID 930 LDTETEQVQG LF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004329	formate-tetrahydrofolate ligase activity
Molecular Function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological Process	GO:0046394	carboxylic acid biosynthetic process
Biological Process	GO:0015942	formate metabolic process
Biological Process	GO:0035999	tetrahydrofolate interconversion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.