Search Results
Overview
| Uniprot ID | F1S8H8 |
|---|---|
| Protein Name | Purine nucleoside phosphorylase |
| Gene Name | PNP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 266 | ILDYECQKKANHEEV |
| 267 | LDYECQKKANHEEVL |
| 278 | EEVLEAGKQAAQKLE |
Function
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine
Protein Sequence
10
MKECGSLDSS
20
KHQQEERFTF
30
EDYQNTAKWL
40
LSHTKHRPQV
50
AVICGSGLGG
60
LTDRLTETQI
70
FNYSEIPNFP
80
RSTVPGHAGR
90
LVFGILNGRA
100
CVMMQGRFHL
110
YEGYPLWKVT
120
FPVRVFQLLG
130
VDTLVVTNAA
140
GGLNPRFEVG
150
DIMLIRDHIN
160
LPGFCGENPL
170
RGPNDERFGV
180
RFPAMSDAYD
190
RDMRQKAHST
200
WKEMGEQREL
210
QEGTYVMVAG
220
PSFETVAECR
230
LLQKLGADAV
240
GMSTVPEVIV
250
ARHCGLRVFG
260
FSLITNKVIL
270
DYECQKKANH
280
EEVLEAGKQA
290
AQKLEQFVSI
300
LIAGIPPPKA
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0001882 | nucleoside binding |
| Molecular Function | GO:0042301 | phosphate ion binding |
| Molecular Function | GO:0002060 | purine nucleobase binding |
| Molecular Function | GO:0004731 | purine-nucleoside phosphorylase activity |
| Biological Process | GO:0000255 | allantoin metabolic process |
| Biological Process | GO:0046059 | dAMP catabolic process |
| Biological Process | GO:0006157 | deoxyadenosine catabolic process |
| Biological Process | GO:0006149 | deoxyinosine catabolic process |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0006204 | IMP catabolic process |
| Biological Process | GO:0006738 | nicotinamide riboside catabolic process |
| Biological Process | GO:0009165 | nucleotide biosynthetic process |
| Biological Process | GO:0032743 | positive regulation of interleukin-2 production |
| Biological Process | GO:0006166 | purine ribonucleoside salvage |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.