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Overview

Uniprot IDF1S8K5
Protein NameFACT complex subunit
Gene NameSUPT16H
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
192 SWNDCLNKEGFDKID
259 KLAESVEKAIEEKKY
316 CAMGIRFKSYCSNLV
462 TSVKKKVKNVGIFLK
515 EKRRAHQKELAAQLN
540 KGEQQIQKARKSNVS
662 QNAFRIIKEVQKRYK
732 FTSVRGDKVDILYNN
817 HKLKTAFKNFIEKVE

Function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II)

Protein Sequence

10 MLPGHWESAG 20 FRGRERVAEP 30 GPRVILGTRG 40 GAASVAMAVT 50 LDKDAYYRRV 60 KRLYSNWRKG 70 EDEYANVDAI 80 VVSVGVDEEI 90 VYAKSTALQT 100 WLFGYELTDT 110 IMVFCDDKII 120 FMASKKKVEF 130 LKQIANTKGN 140 ENANGAPAIT 150 LLIREKNESN 160 KSSFDKMIEA 170 IKESKNGKKI 180 GVFSKDKFPG 190 EFMKSWNDCL 200 NKEGFDKIDI 210 SAVVAYTIAV 220 KEDGELNLMK 230 KAASITSEVF 240 NKFFKERVME 250 IVDADEKVRH 260 SKLAESVEKA 270 IEEKKYLAGA 280 DPSTVEMCYP 290 PIIQSGGNYN 300 LKFSVVSDKN 310 HMHFGAITCA 320 MGIRFKSYCS 330 NLVRTLMVDP 340 SQEVQENYNF 350 LLQLQEELLK 360 ELRHGVKICD 370 VYNAVMDVVK 380 KQKPELLNKI 390 TKNLGFGMGI 400 EFREGSLVIN 410 SKNQYKLKKG 420 MVFSINLGFS 430 DLTNKEGKKP 440 EEKTYALFIG 450 DTVLVDEDGP 460 ATVLTSVKKK 470 VKNVGIFLKN 480 EDEEEEEEEK 490 DEAEDLLGRG 500 SRAALLTERT 510 RNEMTAEEKR 520 RAHQKELAAQ 530 LNEEAKRRLT 540 EQKGEQQIQK 550 ARKSNVSYKN 560 PSLMPKEPHI 570 REMKIYIDKK 580 YETVIMPVFG 590 IATPFHIATI 600 KNISMSVEGD 610 YTYLRINFYC 620 PGSALGRNEG 630 NIFPNPEATF 640 VKEITYRASN 650 MKAPGEQTVP 660 ALNLQNAFRI 670 IKEVQKRYKT 680 REAEEKEKEG 690 IVKQDSLVIN 700 LNRSNPKLKD 710 LYIRPNIAQK 720 RMQGSLEAHV 730 NGFRFTSVRG 740 DKVDILYNNI 750 KHALFQPCDG 760 EMIIVLHFHL 770 KNAIMFGKKR 780 HTDVQFYTEV 790 GEITTDLGKH 800 QHMHDRDDLY 810 AEQMEREMRH 820 KLKTAFKNFI 830 EKVEALTKEE 840 LEFEVPFRDL 850 GFNGAPYRST 860 CLLQPTSSAL 870 VNATEWPPFV 880 VTLDEVELIH 890 FERVQFHLKN 900 FDMVIVYKDY 910 SKKVTMINAI 920 PVASLDPIKE 930 WLNSCDLKYT 940 EGVQSLNWTK 950 IMKTIVDDPE 960 GFFEQGGWSF 970 LEPEGEGSDA 980 EEGDSESEIE 990 DETFNPSEDD 1000 YEEEEEDSDE 1010 DYSSEAEESD 1020 YSKESLGSEE 1030 ESGKDWDELE 1040 EEARKADRES 1050 RYEEEEEQSR 1060 SMSRKRKASV 1070 HSSGRGSNRG 1080 SRHSSAPPKK KRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035101 FACT complex
Molecular Function GO:0031491 nucleosome binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006337 nucleosome disassembly
Biological Process GO:0032786 positive regulation of DNA-templated transcription, elongation
Biological Process GO:0032784 regulation of DNA-templated transcription elongation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.