Search Results
Overview
| Uniprot ID | F1S8R2 |
|---|---|
| Protein Name | Pyrroline-5-carboxylate reductase |
| Gene Name | PYCR2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 131 | QAFQPAPKVIRCMTN |
| 298 | KVPAAALKKTLLDRV |
Function
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+)
Protein Sequence
10
MSVGFIGAGQ
20
LACALARGFT
30
AAGILSAHKI
40
IASSPEMDLP
50
TVAALRKMGV
60
NLTRSNKETV
70
RHSDVLFLAV
80
KPHIIPFILD
90
EIGADVQARH
100
IVVSCAAGVT
110
ISSVEKVPIS
120
GLASLVPLLP
130
QKLQAFQPAP
140
KVIRCMTNTP
150
VVVREGATVY
160
ATGTHALVED
170
GQLLEQLMSS
180
VGFCTEVEED
190
LIDAVTGLSG
200
SGPAYAFMAL
210
DALADGGVKM
220
GLPRRLAVRL
230
GAQALLGAAK
240
MLLDSEQHPG
250
QLKDNVCSPG
260
GATIHALHFL
270
ESGGFRSLLI
280
NAVEASCIRT
290
RELQSMADQE
300
KVPAAALKKT
310
LLDRVKLESP
320
TVSTLTPSSS
330
GKLLTRSPAP
GGKKD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004735 | pyrroline-5-carboxylate reductase activity |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0055129 | L-proline biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.