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Overview

Uniprot IDF1S982
Protein NameCoatomer subunit beta
Gene NameCOPB1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
107 LVCDAYRKDLQHPNE
298 KESDNNVKLIVLDRL
309 LDRLIELKEHPAHER
32 SLKNDLEKGDVKSKT
366 VLKKEVIKTNNVSEH
535 SSSRPTKKEEERPPL
575 YVALVQEKKKQNSFV
602 LGKSSLPKKPITDDD
603 GKSSLPKKPITDDDV
651 SAKLEEEKLSQKKES
703 AMGNTQRKEAADPLA
75 PLQDHTIKKLLLVFW
771 GDLKLVEKPSPLTLA
786 PHDFANIKANVKVAS
876 ILKSTNMKCLTPEKA
949 DKINLSQKKTSI***

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins

Protein Sequence

10 MTAAENVCYT 20 LINVPMDSEP 30 PSEISLKNDL 40 EKGDVKSKTE 50 ALKKVIIMIL 60 NGEKLPGLLM 70 TIIRFVLPLQ 80 DHTIKKLLLV 90 FWEIVPKTTP 100 DGRLLHEMIL 110 VCDAYRKDLQ 120 HPNEFIRGST 130 LRFLCKLKEA 140 ELLEPLMPAI 150 RACLEHRHSY 160 VRRNAVLAIY 170 TIYRNFEHLI 180 PDAPELIHDF 190 LVNEKDASCK 200 RNAFMMLIHA 210 DQDRALDYLS 220 TCIDQVQTFG 230 DILQLVIVEL 240 IYKVCHANPS 250 ERARFIRCIY 260 NLLQSSSPAV 270 KYEAAGTLVT 280 LSSAPTAIKA 290 AAQCYIDLII 300 KESDNNVKLI 310 VLDRLIELKE 320 HPAHERVLQD 330 LVMDILRVLS 340 TPDLEVRKKT 350 LQLALDLVSS 360 RNVEELVIVL 370 KKEVIKTNNV 380 SEHEDTDKYR 390 QLLVRTLHSC 400 SVRFPDMAAN 410 VIPVLMEFLS 420 DSNEAAAADV 430 LEFVREAIQR 440 FDNLRMLIVE 450 KMLEVFHAIK 460 SVKIYRGALW 470 ILGEYCSTKE 480 DIQSVMTEVR 490 RSLGEIPIVE 500 SEIKKEAGEL 510 KPEEEITVGP 520 VQKLVTEMGT 530 YATQSALSSS 540 RPTKKEEERP 550 PLRGFLLDGD 560 FFVAASLATT 570 LTKIALRYVA 580 LVQEKKKQNS 590 FVAEAMLLMA 600 TILHLGKSSL 610 PKKPITDDDV 620 DRISLCLKVL 630 SECSPLMNDI 640 FNKECRQSLS 650 HMLSAKLEEE 660 KLSQKKESEK 670 RNVTVQPDDP 680 ISFMQLTAKN 690 EMNCKEDQFQ 700 LSLLAAMGNT 710 QRKEAADPLA 720 SKLNKVTQLT 730 GFSDPVYAEA 740 YVHVNQYDIV 750 LDVLVVNQTS 760 DTLQNCTLEL 770 ATLGDLKLVE 780 KPSPLTLAPH 790 DFANIKANVK 800 VASTENGIIF 810 GNIVYDVSGA 820 ASDRNCVVLS 830 DIHIDIMDYI 840 QPATCTDAEF 850 RQMWAEFEWE 860 NKVTVNTNII 870 DLNDYLQHIL 880 KSTNMKCLTP 890 EKALSGYCGF 900 MAANLYARSI 910 FGEDALANVS 920 IEKPIQQGPE 930 APVTGHIRIR 940 AKSQGMALSL 950 GDKINLSQKK TSI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000139 Golgi membrane
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0006891 intra-Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.