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Overview

Uniprot IDF1S9U7
Protein NamePaired amphipathic helix protein Sin3b
Gene NameSIN3B
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
197 QKEQLSTKGRPFRGM
408 PKTYQQPKCSGRTAI

Function

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription

Protein Sequence

10 MAHAGGGGGG 20 GPAGRGLSGA 30 RWGRSGSAGH 40 EKLPVHVEDA 50 LTYLDQVKIR 60 FGSDPATYNG 70 FLEIMKEFKS 80 QSIDTPGVIR 90 RVSQLFHEHP 100 DLIVGFNAFL 110 PLGYRIDIPK 120 NGKLNIQSPL 130 SSQENSHNHS 140 DCAENFKQQM 150 PYKEDKPQVP 160 LESDSVEFNN 170 AISYVNKIKT 180 RFLDHPEIYR 190 SFLEILHTYQ 200 KEQLSTKGRP 210 FRGMSEEEVF 220 TEVANLFRGQ 230 EDLLSEFGQF 240 LPEAKRSLFT 250 GNGPCEMSSV 260 QKSEHEKNLE 270 HSKKRSRPSL 280 LRPVSAPAKK 290 KMKLRGTKDL 300 SIATVGKYGT 310 LQEFSFFDKV 320 RRVLKSQEVY 330 ENFLRCIALF 340 NQELVSGSEL 350 LQLVSPFLGK 360 FPELFAQFKS 370 FLGVKELSFA 380 PPMSDRSGDG 390 ISREIDYASC 400 KRIGSSYRAL 410 PKTYQQPKCS 420 GRTAICKEVL 430 NDTWVSFPSW 440 SEDSTFVSSK 450 KTPYEEQLHR 460 CEDERFELDV 470 VLETNLATIR 480 VLESVQKKLS 490 RMAPEDQEKF 500 RLDDCLGGTS 510 EVIQRRAIHR 520 IYGDKAPEII 530 ESLKKNPVTA 540 VPVVLKRLKA 550 KEEEWREAQQ 560 GFNKIWREQY 570 EKAYLKSLDH 580 QAVNFKQNDT 590 KALRSKSLLN 600 EIESVYDEHQ 610 EQHSEGRSAP 620 SSEPHLIFVY 630 EDRQILEDAA 640 ALISYYVKRQ 650 PAIQKEDQGT 660 IHQLVHQFVP 670 SLFFSQQLDL 680 GASEDSADEG 690 RGSPQGQSTD 700 PGDRKKPAPG 710 PQSSPPEEKG 720 AAGEASAAEQ 730 QPPQHKPLDD 740 VYSLFFANNN 750 WYFFLRLHQT 760 LCSRLLKIYR 770 QAQKQLLEYR 780 TEKEREKLLC 790 EGRREKGNDP 800 AMELRLKQPS 810 EVELEEYYPA 820 FLDMVRSLLE 830 GSIDPTQYED 840 TLREMFTIHA 850 YVGFTMDKLV 860 QSIARQLHHL 870 VSDDVCLKVV 880 ELYLNEKKRG 890 AAGGNLSSRC 900 VRAARETSYQ 910 WKAERCMADE 920 NCFKVMFLQR 930 KGQVIMTIEL 940 LDTEEAQTED 950 PVEVQHLARY 960 VEQYVGTEGA 970 SSSPTEGFLL 980 KPVFLQRNLK 990 KFRRWQCEQV 1000 RALRGEAKSS 1010 WKRLVGVESA 1020 CNVDCRFKLS 1030 THKMMFIVNS 1040 EDYMYRRGTL 1050 CRAKQVQPLV 1060 LLRHHQHFEE 1070 WHSRWLEDNV 1080 TVEAASLVQD 1090 WLMGEEDEDM 1100 VPCKTLCETA 1110 HVHGLPVTRY 1120 RVQYSRRPAS P

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030849 autosome
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070822 Sin3-type complex
Cellular Component GO:0000805 X chromosome
Cellular Component GO:0001741 XY body
Cellular Component GO:0000806 Y chromosome
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.