Search Results
Overview
| Uniprot ID | F1SAA9 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase |
| Gene Name | UCHL5 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 280 | VQKLKRYKIENIRRK |
| 313 | QLIPLVEKAKEKQNA |
Function
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1
Protein Sequence
10
MTGNAGEWCL
20
MESDPGVFTE
30
LIKGFGCRGA
40
QVEEIWSLEP
50
ENFEKLKPVH
60
GLIFLFKWQP
70
GEEPAGSVVQ
80
DSRLDTIFFA
90
KQVINNACAT
100
QAIVSVLLNC
110
THQDVHLGET
120
LSEFKEFSQS
130
FDAAMKGLAL
140
SNSDVIRQVH
150
NSFARQQMFE
160
FDAKTSKEED
170
AFHFVSYVPV
180
NGRLYELDGL
190
REGPIDLGAC
200
NQDDWISAVR
210
PVIEKRIQKY
220
SEGEIRFNLM
230
AIVSDRKMIY
240
EQKIAELQRQ
250
LAEEPMDTDQ
260
GSNMLSAIQS
270
EVAKNQMLIE
280
EEVQKLKRYK
290
IENIRRKHNY
300
LPFIMELLKT
310
LAEHQQLIPL
320
VEKAKEKQNA
KKAQETK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031011 | Ino80 complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000502 | proteasome complex |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Molecular Function | GO:0004866 | endopeptidase inhibitor activity |
| Molecular Function | GO:0070628 | proteasome binding |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0048853 | forebrain morphogenesis |
| Biological Process | GO:0021670 | lateral ventricle development |
| Biological Process | GO:0030901 | midbrain development |
| Biological Process | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0045739 | positive regulation of DNA repair |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045880 | positive regulation of smoothened signaling pathway |
| Biological Process | GO:1904507 | positive regulation of telomere maintenance in response to DNA damage |
| Biological Process | GO:0016579 | protein deubiquitination |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0033044 | regulation of chromosome organization |
| Biological Process | GO:0006275 | regulation of DNA replication |
| Biological Process | GO:0060382 | regulation of DNA strand elongation |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0000723 | telomere maintenance |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.