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Overview

Uniprot IDF1SAB0
Protein NameParafibromin
Gene NameCDC73
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
331 TEGASARKTQTPAAQ
354 ARPPPNQKKGSRTPI

Function

No function data available.

Protein Sequence

10 MADVLSVLRQ 20 YNIQKKEIVV 30 KGDEVIFGEF 40 SWPKNVKTNY 50 VVWGTGKEGQ 60 PREYYTLDSI 70 LFLLNNVHLS 80 HPVYVRRAAT 90 ENIPVVRRPD 100 RKDLLGYLNG 110 EASTSASIDR 120 SAPLEIGLQR 130 STQVKRAADE 140 VLAEAKKPRI 150 EDEECVRLDK 160 ERLAARLEGH 170 KEGIVQTEQI 180 RSLSEAMSVE 190 KIAAIKAKIM 200 AKKRSTIKTD 210 LDDDITALKQ 220 RSFVDAEVDV 230 TRDIVSRERV 240 WRTRTTILQS 250 TGKNFSKNIF 260 AILQSVKARE 270 EGRAPEQRPA 280 PNAAPVDPTL 290 RTKQPIPAAY 300 NRYDQERFKG 310 KEETEGFKID 320 TMGTYHGMTL 330 KSVTEGASAR 340 KTQTPAAQPV 350 PRPVSQARPP 360 PNQKKGSRTP 370 IIIIPAATTS 380 LITMLNAKDL 390 LQDLKFVPSD 400 EKKKQGCQRE 410 NETLIQRRKD 420 QMQPGGTAIS 430 VTVPYRVVDQ 440 PLKLMPQDWD 450 RVVAVFVQGP 460 AWQFKGWPWL 470 LPDGSPVDIF 480 AKIKAFHLKY 490 DEVRLDPNVQ 500 KWDVTVLELS 510 YHKRHLDRPV 520 FLRFWETLDR 530 YMVKHKSHLR F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016593 Cdc73/Paf1 complex
Molecular Function GO:0000993 RNA polymerase II complex binding
Biological Process GO:0031124 mRNA 3'-end processing
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:0048147 negative regulation of fibroblast proliferation
Biological Process GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0045638 negative regulation of myeloid cell differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:1902808 positive regulation of cell cycle G1/S phase transition
Biological Process GO:0031442 positive regulation of mRNA 3'-end processing
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0030177 positive regulation of Wnt signaling pathway
Biological Process GO:0031648 protein destabilization
Biological Process GO:0006368 transcription elongation by RNA polymerase II

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.