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Overview

Uniprot ID	F1SAE9
Protein Name	Laminin subunit beta-1
Gene Name	LAMB1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1207	LEKAKALKISGVIGP
239	NLRIKFVKLHTLGDN
635	ITVQRPGKIPTSSRC

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway

Protein Sequence

10 MGRLQVFALS 20 FLALCGAQVS 30 AQEPEFSYGC 40 AEGSCYPATG 50 DLLIGRAQKL 60 SVTSTCGLHK 70 PEPYCIVSHL 80 QEDKKCFICN 90 SQDPYHETLN 100 PDSHLIENVV 110 TTFAPNRLKI 120 WWQSENGVEN 130 VTIQLDLEAE 140 FHFTHLIMTF 150 KTFRPAAMLI 160 ERSSDFGRTW 170 GVYRYFAYDC 180 ESSFPGIPTG 190 PMKKVDDIIC 200 DSRYSDIEPS 210 TEGEVIFRAL 220 DPAFRIEDPY 230 SPRIQNLLKI 240 TNLRIKFVKL 250 HTLGDNLLDS 260 RMEIREKYYY 270 AVYDMVVRGN 280 CFCYGHASEC 290 APVDGFNEEV 300 EGMVHGHCMC 310 RHNTKGLNCE 320 LCMDFYHDLP 330 WRPAEGRNSN 340 ACKKCNCNEH 350 SSSCHFDMAV 360 YLATGNVSGG 370 VCDDCQHNTM 380 GRNCERCKPF 390 YYQHPERDVR 400 DPNLCEPCTC 410 DPAGSQNGIC 420 DGYTDFSAGL 430 IAGQCRCKLH 440 VEGEHCDICK 450 EGFYGLTAED 460 PFGCKSCACN 470 PLGTIPGGNP 480 CDSETGYCYC 490 KRLVTGQHCD 500 QCLPEHWGLS 510 NDLDGCRPCD 520 CDLGGALNNS 530 CSAESGQCLC 540 RPHMIGRQCN 550 EVESGFYFTT 560 LDHYIYEAEE 570 ANFGPGVSIV 580 ERQYVQDRIP 590 SWTGAGFVRV 600 PEGAYLEFFI 610 DNIPYSMEYD 620 ILIRYEPQLP 630 DHWEKAVITV 640 QRPGKIPTSS 650 RCGNTVPDDD 660 NQVVSLSPGS 670 RYVVLPRPVC 680 FEKGVNYTVR 690 LELPQYTSSD 700 SSVDSPYTLI 710 DSLVLMPFCK 720 SLDIFTVGSS 730 GDGVVTNSAW 740 EMFQRYRCLE 750 NSRSVVKTPM 760 TDVCRNIIFS 770 ISALLHQTGL 780 ACECDPQGSL 790 SSVCDPNGGQ 800 CQCRPNVVGR 810 KCDRCAPGTF 820 GFGPNGCKPC 830 ECHLQGSVNA 840 FCDPVTGQCH 850 CFQGVYARQC 860 DRCLPGYWGF 870 PSCQPCQCNG 880 HAEDCDSVTG 890 ECSSCQDYTT 900 GHNCERCLAG 910 YYGDAIIGSG 920 DHCRPCPCPD 930 GPESGRQFAS 940 SCYQDPVTLQ 950 LACVCNPGYI 960 GSRCEDCAAG 970 FFGNPSEVGG 980 TCQPCQCHHN 990 IDTTDPEACD 1000 KETGRCLKCL 1010 YHTEGVHCQL 1020 CRLGYYGDAL 1030 QQDCRKCVCN 1040 YLGTVQEHCN 1050 GSDCQCDKTT 1060 GQCLCLPNVI 1070 GQNCDRCAPN 1080 TWQLASGTGC 1090 EPCNCDAAHS 1100 FGPSCNEFTG 1110 QCQCMPGFGG 1120 RTCSECQELF 1130 WGDPSVECRA 1140 CDCDPRGIET 1150 PQCDQSTGQC 1160 VCVEGVEGPR 1170 CDKCTRGYSG 1180 VFPDCTPCHQ 1190 CFALWDVIIA 1200 ELTNRTQKFL 1210 EKAKALKISG 1220 VIGPYRETVD 1230 SVEKKVNEIR 1240 DILAQSPAAE 1250 PLKNIGNLFE 1260 EAEKLTKDVT 1270 EKMAQVEGKL 1280 SDAALQSNST 1290 ARELDSLQAE 1300 AESLENTVKE 1310 LAEQLEFIKN 1320 SDIRGALDSI 1330 TKYFQMSLEA 1340 EERVNASTTD 1350 SNSTVEQSAL 1360 IRDRVEDLML 1370 EQESQFRDKQ 1380 EEQARLLDEL 1390 AGKLQSLDLS 1400 TAAELTCGTP 1410 PGASCSETEC 1420 GGPNCRTDEG 1430 QKKCGGPGCG 1440 GLVTVAHSAW 1450 QKAMDFDQDV 1460 LSALAEVEQL 1470 SKMVSEAKLR 1480 ADEAKQNAQD 1490 VLLKANATKE 1500 KVDKSNEDLR 1510 NLIKQIRDFL 1520 TQDSADLDSI 1530 EAVANEVLKM 1540 EMPSTPQQLQ 1550 NLTEDIRERV 1560 ESLSQVEVIL 1570 QQSAADIARA 1580 ELLLEEAQRA 1590 SKSATDVKVT 1600 ADMVKEALEE 1610 AEKAQIAAEK 1620 AIKQADEDIQ 1630 GTQNLLTSIE 1640 SETAASEETL 1650 FNASQRISEL 1660 ERNVEELKRK 1670 AAQNSGEAEY 1680 IEKVVYAVKQ 1690 SADDVKKTLD 1700 GELEEKYKKV 1710 ENLIAQKTEE 1720 SADARRKAEM 1730 LQNEAKTLLA 1740 QANSKLQLLK 1750 DLERKYEDNQ 1760 KYLEDKAQEL 1770 VRLEGEVRSL 1780 LKDISQKVAV YSTCL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0043256	laminin trimer
Cellular Component	GO:0005606	laminin-111 trimer
Cellular Component	GO:0005607	laminin-211 trimer
Cellular Component	GO:0043257	laminin-411 trimer
Cellular Component	GO:0043259	laminin-511 trimer
Molecular Function	GO:0005201	extracellular matrix structural constituent
Molecular Function	GO:0005178	integrin binding
Biological Process	GO:0009887	animal organ morphogenesis
Biological Process	GO:0007411	axon guidance
Biological Process	GO:0070831	basement membrane assembly
Biological Process	GO:0016477	cell migration
Biological Process	GO:0035987	endodermal cell differentiation
Biological Process	GO:0021812	neuronal-glial interaction involved in cerebral cortex radial glia guided migration
Biological Process	GO:0042476	odontogenesis
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading
Biological Process	GO:0009888	tissue development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.