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Overview

Uniprot IDF1SAH7
Protein NameVacuolar protein sorting-associated protein 11 homolog
Gene NameVPS11
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
743 EYVAAVLKHIESKNL

Function

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes

Protein Sequence

10 MAAYLQWRRF 20 VFFDKELVKE 30 PLGNDGAAPG 40 PAPASAPAAS 50 KFLCLPPGIT 60 VCDSGRGSLV 70 FGDMEGQIWF 80 LPRSLQLTGF 90 QAYKLRVTHL 100 YQLKQHNILA 110 SVGEDEEGIN 120 PLVKIWNLEK 130 RDGGNPLCTR 140 IFPAIPGTEP 150 TVVSCLTVHE 160 NLNFMAIGFT 170 DGSVTLNKGD 180 ITRDRHSKTQ 190 ILHKGNYPVT 200 GLAFRQAGKT 210 THLFVVTTEN 220 VQSYIVSGKD 230 YPRVELDTHG 240 CGLRCSALSD 250 PSQDMQFIVA 260 GDECVYLYQP 270 DERGPCFAFE 280 GHKLIAHWFR 290 GYLVIVSRDR 300 KVSPKSEFTS 310 RDSQSSDKQI 320 LNIYDLCNKF 330 IAYSAVFEDV 340 VDVLAEWGSL 350 YVLTRDGRVH 360 ALQEKDTQTK 370 LEMLFKKNLF 380 EMAINLAKSQ 390 HLDSDGLAQI 400 FMQYGDHLYS 410 KGNHDGAVQQ 420 YIRTIGKLEP 430 SYVIRKFLDA 440 QRIHNLTAYL 450 QTLHRQSLAN 460 ADHTTLLLNC 470 YTKLKDSSKL 480 EEFIKTKSES 490 EVHFDVETAI 500 KVLRQAGYYS 510 HALYLAENHA 520 HHEWYLKIQL 530 EDIKNYQEAL 540 RYIGKLPFEQ 550 AESNMKRYGK 560 TLMHHIPEQT 570 TQLLKGLCTN 580 YQPSLEGRGD 590 REAPGCRANS 600 EEFIPIFANN 610 PRELKAFLEH 620 MSEVQPDSPQ 630 GIYDTLLELR 640 LQNWAHEEDP 650 QVKEKLHAEA 660 ISLLKSGRFC 670 DVFDKALVLC 680 QMHDFQDGVL 690 YLYEQGKLFQ 700 QIMHYHMQHE 710 QYRQVIAVCE 720 RHGEQEPSLW 730 EQALSYFARK 740 EEDCKEYVAA 750 VLKHIESKNL 760 MPPLLVVQTL 770 AHNSTATLSV 780 IRDYLVQKLQ 790 KQSQQIAQDE 800 LRVRRYREET 810 TRIRQEIQEL 820 KASPKIFQKT 830 KCSICNSALE 840 LPSVHFLCGH 850 SFHQHCFESY 860 SESDADCPTC 870 LPENRKVMDM 880 IRAQEQKRDL 890 HDQFQHQLKC 900 SNDSFSVIAD 910 YFGRGVFNKL 920 TLLTDPPPAR 930 LTSSLEAGLQ 940 RDLLMHSRRG T

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005884 actin filament
Cellular Component GO:0030123 AP-3 adaptor complex
Cellular Component GO:0005776 autophagosome
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0033263 CORVET complex
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005768 endosome
Cellular Component GO:0030897 HOPS complex
Cellular Component GO:0031902 late endosome membrane
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0048786 presynaptic active zone
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006914 autophagy
Biological Process GO:0007032 endosome organization
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0048284 organelle fusion
Biological Process GO:0007033 vacuole organization
Biological Process GO:0006904 vesicle docking involved in exocytosis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.