Search Results

Overview

Uniprot IDF1SAI8
Protein NameHypoxia up-regulated protein 1
Gene NameHYOU1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
391 GGATRVPKVQEVLLK
398 KVQEVLLKAVGKEEL
463 EPGVHSLKHNKRILF
522 NLTTVKLKGVGESFR
722 ELARSAQKLQDLTLR
797 TTAMLKEKLAELRKL
803 EKLAELRKLCQGLFF
883 AKLPATEKPVLLSKD
889 EKPVLLSKDIEAKMM

Function

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress. May play a role as a molecular chaperone and participate in protein folding

Protein Sequence

10 MAAMVRRQRP 20 RRLACWALMA 30 VLLADLLALS 40 DTLAVMSVDL 50 GSESMKVAIV 60 KPGVPMEIVL 70 NKESRRKTPV 80 TVTLKENERF 90 FGDSAASMAI 100 KNPKATLRYF 110 QHLLGKQENN 120 PHVALYRARF 130 PEHELGFDPQ 140 RQTVYFQISP 150 QLQFSPEEVL 160 SMLLNYSRSL 170 AEDFAEQPIK 180 DAVITVPAFF 190 NQAERRAVLQ 200 AARMAGLKVL 210 QLINDNTATA 220 LSYGVFRRKD 230 INTTAQNIMF 240 YDMGAGSTVC 250 TIVTYQTVKT 260 KDSGVQPQLQ 270 IRGVGFDRTL 280 GGLEMELRLR 290 EHLARLFNEQ 300 RKGQRAKDVR 310 ENPRAMAKLL 320 REANRLKTVL 330 SANADHMAQI 340 EGLMDDVDFK 350 AKVTRAEFED 360 LCADLFERVP 370 GPVQQALQSA 380 EMKLDEIEQV 390 ILVGGATRVP 400 KVQEVLLKAV 410 GKEELGKNIN 420 ADEAAAMGAV 430 YQAAALSKAF 440 KVKPFVVRDA 450 VIYPILVEFT 460 REVEEEPGVH 470 SLKHNKRILF 480 SRMGPYPQRK 490 VITFNRYSHD 500 FNFHINYGDL 510 GFLGPEDLRV 520 FGSQNLTTVK 530 LKGVGESFRK 540 YPDYESKGIK 550 AHFNLDESGV 560 LSLDRVESVF 570 ETLVEDSPEE 580 ESTLTKLGNT 590 ISSLFGGGAT 600 PDAKENGTDS 610 VQEEEEGPAE 620 GSKDEPGEQA 630 ELKEEADSPT 640 EDASPPPPPE 650 PKGSAAPEGE 660 KTTEKDDGEK 670 PEAQKPSDKG 680 EAGFESVPPA 690 PEEEKKQKPA 700 RKQRMVEEIG 710 VELVVLDLPD 720 LPEDELARSA 730 QKLQDLTLRD 740 LEKQEREKAA 750 NSLEAFIFET 760 QDKLYQPEYQ 770 EVSTEEQRED 780 ISGKLSATSS 790 WLEDEGFGAT 800 TAMLKEKLAE 810 LRKLCQGLFF 820 RVEERKKWPE 830 RLSALDSLLN 840 HSSMFLKGAR 850 LIPEMDQIFT 860 EVEMTTLEKV 870 INETWAWKNA 880 TMAEQAKLPA 890 TEKPVLLSKD 900 IEAKMMALDR 910 EVQYLLNKAK 920 FAKPRPRPKD 930 KNGTRAEPPL 940 NASASDQGDK 950 VIPPPGQTED 960 AKPISEPEKE 970 TQAGSEPAGS 980 EPLELGGPGA 990 ESEQKEQPTE 1000 QKRTLKNDEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005788 endoplasmic reticulum lumen
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Biological Process GO:0080135 regulation of cellular response to stress
Biological Process GO:0006950 response to stress

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.