Search Results
Overview
| Uniprot ID | F1SAJ5 |
|---|---|
| Protein Name | Probable ATP-dependent RNA helicase DDX6 |
| Gene Name | DDX6 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | EFEDYCLKRELLMGI |
| 231 | GRILDLIKKGVAKVD |
| 352 | QRVELLAKKISQLGY |
Function
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts
Protein Sequence
10
MSTARTENPV
20
IMGLSSQNGQ
30
LRGPVKPSGG
40
PGGGGTQTQQ
50
QMNQLKNTNT
60
INNGTQQQAQ
70
SMTATIKPGD
80
DWKKTLKLPP
90
KDLRIKTSDV
100
TSTKGNEFED
110
YCLKRELLMG
120
IFEMGWEKPS
130
PIQEESIPIA
140
LSGRDILARA
150
KNGTGKSGAY
160
LIPLLERLDL
170
KKDNIQAMVI
180
VPTRELALQV
190
SQICIQVSKH
200
MGGAKVMATT
210
GGTNLRDDIM
220
RLDDTVHVVI
230
ATPGRILDLI
240
KKGVAKVDHV
250
QMIVLDEADK
260
LLSQDFVQIM
270
EDIILTLPKN
280
RQILLYSATF
290
PLSVQKFMNS
300
HLQKPYEINL
310
MEELTLKGVT
320
QYYAYVTERQ
330
KVHCLNTLFS
340
RLQINQSIIF
350
CNSSQRVELL
360
AKKISQLGYS
370
CFYIHAKMRQ
380
EHRNRVFHDF
390
RNGLCRNLVC
400
TDLFTRGIDI
410
QAVNVVINFD
420
FPKLAETYLH
430
RIGRSGRFGH
440
LGLAINLITY
450
DDRFNLKSIE
460
EQLGTEIKPI
470
PSNIDKSLYV
480
AEYHSEPVED
EKP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000932 | P-body |
| Cellular Component | GO:0016442 | RISC complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0003724 | RNA helicase activity |
| Biological Process | GO:0017148 | negative regulation of translation |
| Biological Process | GO:0033962 | P-body assembly |
| Biological Process | GO:0034063 | stress granule assembly |
| Biological Process | GO:0019074 | viral RNA genome packaging |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.