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Overview

Uniprot ID	F1SAM8
Protein Name	Serine/threonine-protein kinase MRCK beta
Gene Name	CDC42BPB
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1213	VRVADYKKVYQIELA

Function

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation

Protein Sequence

10 MQLHREDFEI 20 IKVIGRGAFG 30 EVAVVRMKST 40 ERIYAMKILN 50 KWEMLKRAET 60 ACFREERDVL 70 VNGDSQWLTT 80 LHYAFQDENY 90 LYLVMDYYVG 100 GDLLTLLSKF 110 EDRLPEDMAR 120 FYIGEMVLAI 130 DSIHQLHYVH 140 RDIKPDNVLL 150 DVNGHIRLAD 160 FGSCLKMNDD 170 GTVQSSVAVG 180 TPDYISPEIL 190 QAMEDGMGRY 200 GPECDWWSLG 210 VCMYEMLYGE 220 TPFYAESLVE 230 TYGKIMNHEE 240 RFQFPSHVTD 250 VSEEAKDLIQ 260 RLICSRERRL 270 GQNGVEDFKK 280 HAFFQGLNWE 290 TIRNLEAPYI 300 PDVSSPSDTS 310 NFDVDDDVLR 320 NVEILPPASH 330 TGFSGLHLPF 340 IGFTFTTESC 350 FSDRGSLKSI 360 MQSSTLTKDE 370 GLQRDLENSL 380 QVEAYERRIR 390 RLEQERLELS 400 RKLQEATQTV 410 QSFHGAARTL 420 GSAARDKEIK 430 KLNEEIERLK 440 NKIAESNKLE 450 RQLEDTVTLR 460 QEQEDSTHRL 470 KGLEKQYRAV 480 RQEKEDFHKQ 490 LIEASERLKS 500 QARELKDAHQ 510 QRKLALQEFS 520 ELNERMAELR 530 SQKQKVSRQL 540 RDREEEVEAA 550 LQKIDALRQE 560 VRRADKCRKE 570 LEAQLEDAVA 580 EASKERKLRE 590 HSENFSKQIE 600 SELEALKMKQ 610 GGRGPGAALE 620 HQQEISRIKS 630 ELEKKVLFYE 640 EELVRREASH 650 VLELKTVKKE 660 VHDSEGHQLA 670 LQKEVLVLKD 680 KLEKSKRERH 690 SELEEAVGTV 700 KDKYERERAV 710 LSEENKKLTA 720 ENEKLCAFVD 730 KLTAQNRQLE 740 DELQDLAAKK 750 ESVAHWEAQI 760 AEIIQWVSDE 770 KDARGYLQAL 780 ASKMTEELEA 790 LRSSSLGSRT 800 LDPLWKVRRS 810 QKLDMSARLE 820 LQSALEAEIR 830 AKQLVQEELR 840 KVKDMNLSFE 850 SKLKDSEAKN 860 RELLEEMEIL 870 KKKMEEKFRT 880 DAGLKLPDFQ 890 DSIFEYFNTA 900 PLAHDLTFRA 910 SSASEQETQA 920 AKPEAMPPSS 930 VAASTEQQED 940 VARAPQRPPT 950 VPLPSTQALA 960 LAGPKPKAHQ 970 FSIKSFSSPT 980 QCSHCTSLMV 990 GLIRQGYACD 1000 VCSFACHVSC 1010 RDSAPQVCPI 1020 PPEQSKRPLG 1030 VDVQRGIGTA 1040 YKGYVKVPKP 1050 TGVKKGWQRA 1060 YAVVCDCKLF 1070 LYDLPEGKST 1080 QPGVVASQVL 1090 DLRDEEFSVS 1100 SVLASDVIHA 1110 SRRDIPCIFR 1120 VTASLLGTPS 1130 KTSSLLILTE 1140 NENEKRKWVG 1150 ILEGLQSILQ 1160 KNRLRSQVVH 1170 SPQEAYDSSL 1180 PLIKAVLAAA 1190 ILDADRIAVG 1200 LEEGLYVVEV 1210 TRDVIVRVAD 1220 YKKVYQIELA 1230 PKEKVAALLC 1240 GRNHHVHLCP 1250 WSSFDGAEGT 1260 VDIKLPETKG 1270 CQLIATGAPK 1280 KSSPTCLFVA 1290 VKRLVLCYEM 1300 QRTKPFHRKL 1310 SELAAPGPVQ 1320 WMAVLKDKLC 1330 VGYPSGFSLL 1340 SPQGEGQALN 1350 LVNPNDPSLT 1360 FLSQQSFDAL 1370 CAVELQSEEY 1380 LLCFSHMGLY 1390 VDPQGRRSRM 1400 QELMWPAAPV 1410 ACSCSPSHVT 1420 VYSDYGVDVF 1430 DARSMEWVQT 1440 IGLRRIRPLN 1450 SEGSLNLLNC 1460 EPPRLIYFKS 1470 KFAGPALNVP 1480 DTSDNSKKQM 1490 LRTRSKRRFV 1500 FKVPEEERLQ 1510 QRREMLRDPE 1520 LRSRMISNPT 1530 NFNHVAHMGP 1540 GDGMQVLMDL 1550 PLSAVPPSQE 1560 ERPGPAPASL 1570 SRQPPPRNKP 1580 YVSWPSSGGS 1590 EPGVAVPLRS 1600 MSDPDQDFDK 1610 EPDSDSTKHS 1620 TPSNSSNPSG 1630 PPSPNSPHRS 1640 QLPLEGLEQP SYDA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0070161	anchoring junction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0016477	cell migration

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.