Search Results
Overview
| Uniprot ID | F1SAQ3 |
|---|---|
| Protein Name | Cyclin-K |
| Gene Name | CCNK |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 359 | PPPPKIAKIETTHPP |
Function
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A)
Protein Sequence
10
MKENKENSSP
20
SVTSANLDHT
30
KPCWYWDKKD
40
LAHTPSQLEG
50
LDPATEARYR
60
REGARFIFDV
70
GTRLGLHYDT
80
LATGIIYFHR
90
FYMFHSFKQF
100
PRYVTGACCL
110
FLAGKVEETP
120
KKCKDIIKTA
130
RSLLNDVQFG
140
QFGDDPKEEV
150
MVLERILLQT
160
IKFDLQVEHP
170
YQFLLKYAKQ
180
LKGDKNKIQK
190
LVQMAWTFVN
200
DSLCTTLSLQ
210
WEPEIIAVAV
220
MYLAGRLCKF
230
EIQEWTSKPM
240
YRRWWEQFVQ
250
DVPVDVLEDI
260
CHQILDLYSQ
270
GKQQMPHHTP
280
HQLQQPPSLH
290
PAPQVPQVPQ
300
SQSSQGSEAP
310
QPPQKDPQQP
320
AQPQPPPPAQ
330
PPKKPSPQPS
340
PPRQAKRAVV
350
VSPKEENKTA
360
EPPPPKIAKI
370
ETTHPPLPPA
380
HPPPDRKPPL
390
AAALGEAEPP
400
GAVEAGDLPK
410
VQIPPPAHPA
420
PVHQPPPLPH
430
RPPPPPPSSY
440
ITGMSTTSSY
450
MSGEGYQSLQ
460
SMMKTEGPSY
470
GALPPAYGPP
480
AHLPYHPHVY
490
PHPPPPPVPP
500
PPASFPPPAI
510
PPPTPVPPPP
520
PTYNPNFPPP
530
PPRLPPTHAV
540
PPHPPPGLGL
550
PPASYPPPAV
560
PPGGQPPVPP
570
PIPPPGMPPV
580
GGLGRAAWMR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0002944 | cyclin K-CDK12 complex |
| Cellular Component | GO:0002945 | cyclin K-CDK13 complex |
| Cellular Component | GO:0008024 | cyclin/CDK positive transcription elongation factor complex |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity |
| Molecular Function | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0044828 | host-mediated suppression of viral genome replication |
| Biological Process | GO:0032786 | positive regulation of DNA-templated transcription, elongation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II |
| Biological Process | GO:0009966 | regulation of signal transduction |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.