Search Results
Overview
| Uniprot ID | F1SAR5 |
|---|---|
| Protein Name | Glutaredoxin-related protein 5, mitochondrial |
| Gene Name | GLRX5 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 50 | DTLVKKDKVVVFLKG |
Function
Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer. Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1
Protein Sequence
10
MSASLGRAAA
20
ALLRWGRGVG
30
GGLWVPGVRA
40
ASSGGSGSAE
50
HLDTLVKKDK
60
VVVFLKGTPE
70
QPQCGFSNAV
80
VQILRLHGVR
90
DYAAYNVLDD
100
PQLRQGIKDY
110
SNWPTIPQVY
120
LNGEFVGGCD
130
ILLQMHQNGD
140
LVEELKKLGI
150
RSALLDEKTD
QDSK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0044571 | [2Fe-2S] cluster assembly |
| Biological Process | GO:0051604 | protein maturation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.