Overview
| Uniprot ID | F1SB54 |
|---|
| Protein Name | DnaJ homolog subfamily C member 2 |
|---|
| Gene Name | DNAJC2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 491 |
KAFDKFKKEHGVVPQ |
Function
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation
Protein Sequence
10
MGSSPRNRNA
20
SASFQELEDK
30
KELSEESEDE
40
ELQLEEFPML
50
KTLDPKDWKN
60
QDHYAVLGLG
70
HVRYKATQRQ
80
IKAAHKAMVL
90
KHHPDKRKAA
100
GEPIKEGDND
110
YFTCITKAYE
120
MLSDPVKRRA
130
FNSVDPTFDN
140
SVPSKSEAKD
150
NFFEVFSPVF
160
ERNSRWSNKK
170
NVPKLGDMNS
180
SFEDVDAFYS
190
FWYNFDSWRE
200
FSYLDEEEKE
210
KAECRDERRW
220
IEKQNRATRA
230
QRKKEEMNRI
240
RTLVDNAYSC
250
DPRIKKFKEE
260
EKAKKEAEKK
270
AKAEAKRKEQ
280
EAKEKQRQAE
290
LEAARLAKEK
300
EEEEVRQQAL
310
LAKKEKDIQK
320
KAIKKERQKL
330
RNSCKTWNHF
340
SDNEAERVKM
350
MEEVEKLCDR
360
LELSSLQCLN
370
ETLTSSTKEV
380
GKAALEKQIE
390
EINEQIRKEK
400
EEAEARMRQA
410
SKNAEKSTGG
420
GGNGSKHWSE
430
DDLQLLIKAV
440
NLFPAGTNSR
450
WEVIANYMNI
460
HSSSGVKRTA
470
KDVIGKAKSL
480
QKLDPHQKDD
490
INKKAFDKFK
500
KEHGVVPQAD
510
NATPSERFEG
520
PCTDFTPWTT
530
EEQKLLEQAL
540
KTYPVNTPER
550
WEKIAEAVPG
560
RTKKDCMKRY
570
KELVEMVKAK
580
KAAQEQVLNA
SRAKK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0030544 |
Hsp70 protein binding |
| Molecular Function |
GO:0043022 |
ribosome binding |
| Biological Process |
GO:0051083 |
'de novo' cotranslational protein folding |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006450 |
regulation of translational fidelity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.