Overview
| Uniprot ID | F1SB67 |
| Protein Name | Cation-independent mannose-6-phosphate receptor |
| Gene Name | IGF2R |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1231 |
EGDNCSVKDPRHGNL |
| 1265 |
YYFRVCGKLSSDVCP |
| 1278 |
CPTSDRSKVISSCQE |
| 170 |
KDIFKAKKEVPCYVF |
| 1827 |
SLSKSTFKVTRDSRT |
| 1985 |
VTFEWKTKVVCPPKK |
| 2049 |
DRASVCKKNPSGNVQ |
| 303 |
TLPKLTAKSNCRYEV |
| 385 |
DAAVCQVKKADSTQA |
Function
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4
Protein Sequence
10
MGAAAGRSAH
20
LGPAPAGYRL
30
RSLLLVQLLL
40
LVWAPRATGT
50
QGTEFPELCS
60
YTWEAVDTKN
70
NRLYKISICG
80
NVAVAPCGTS
90
SAVCMQDLKT
100
NSFHSVGDSV
110
LKSASRSLLE
120
FNTTVSCGQQ
130
SANHRIQSSI
140
TFLCGKTLGT
150
PEFVTATDCV
160
HYFEWRTTAA
170
CKKDIFKAKK
180
EVPCYVFDRE
190
LKKRDLNPLI
200
KVGGAYLVDD
210
SDPDASLFIN
220
VCRDIDTLRD
230
RAPQLRACPL
240
GTAACLVRGD
250
WAFDVGRPRE
260
GLQLLSNDRL
270
VLSYVNEEPA
280
PPDFCDGHSP
290
AVTITFVCPS
300
ERREGTLPKL
310
TAKSNCRYEV
320
EWVTEYACPR
330
DYLESRNCFL
340
SSEQHDITID
350
LQPLSRVGDA
360
PYTCEGEEYV
370
FSLSVCGGAE
380
TPVCNEKDAA
390
VCQVKKADST
400
QAKVAGRLQN
410
QTLRYSDGDL
420
TLIYFGGDEC
430
SSGFQRMSVI
440
NFECNKTAGN
450
NGKGAPVFTG
460
EVDCTYFFTW
470
DTRYACVEEK
480
EALLCGVADG
490
RQRFDLSALA
500
RHSELEQNWE
510
AVDGSQRGAE
520
KKHFFINICR
530
RVLQEGQARG
540
CPEDAAACAV
550
DESGSKNLGK
560
FISSPTREKG
570
NIQLSYSDGD
580
ECGGGKRINT
590
NITLICKPGD
600
LESAPVLRTS
610
RADGCFYEFE
620
WYTAAACVLS
630
RTEGDNCTVF
640
DAQAGFSFDL
650
SPLTKTNGAY
660
KVETEKYEFY
670
INVCGAVSAS
680
ACQPDSGACQ
690
VSKSDKKSWN
700
LGRSNAKLSY
710
YDGMIQLNYH
720
DGTPYNNERR
730
TPRATLITFL
740
CDRDAGVGLP
750
EYQEEDNSTY
760
NFRWYTSYAC
770
PEEPLECVVT
780
DPSTLEQYDL
790
SSLAKSEGGR
800
GGNWYALDSA
810
GPHSTWRKYY
820
INVCRPLNPV
830
PGCDRYASAC
840
QMKYESHQGS
850
FSETVSISNL
860
GVAKAGPVVE
870
NSGSLVLEYV
880
NGSACTTSDG
890
RRTTYTTRIH
900
LVCSRGSLNT
910
HPIFSLSWEC
920
VVSFLWNTEA
930
ACPVRVTTDT
940
DQACSIRDPN
950
SGYVFDLNPL
960
NRSQGYVLTG
970
IGKTFVFNVC
980
GTMPICGTLD
990
GKLASGCEAE
1000
TETKELKNLR
1010
PGRLVGLEKI
1020
LQLSPEGFIT
1030
LTYTGLPSHP
1040
KGPADAFIIR
1050
FVCNGDLYPG
1060
VPKFLHRDID
1070
SRLGIWNTFF
1080
DFETALACVP
1090
SPVDCLVTDP
1100
EGNEYDLSGL
1110
SRVKKPWTAV
1120
DTTSDGKKRT
1130
FYLSVCNPLP
1140
YIPGCHGSMV
1150
GSCLVSEDKS
1160
LNLGVVQVSP
1170
QVAANGSLSV
1180
VYVNGDTCKD
1190
QRYSTRVILE
1200
CAHTAGSPTF
1210
QLLDDCEYVF
1220
VWRTVEACPV
1230
VRVEGDNCSV
1240
KDPRHGNLYD
1250
LKPLALNDTV
1260
VSAGEYTYYF
1270
RVCGKLSSDV
1280
CPTSDRSKVI
1290
SSCQEKRGPQ
1300
GFQKVAGLLT
1310
QKLTYENGVL
1320
KMNYTGGDTC
1330
HKVYQRSTTI
1340
FFYCDRSTQA
1350
PVFLQETSDC
1360
SYLFEWRTQY
1370
ACPPFDLTEC
1380
SFKDAAGNTF
1390
DLSSLARYSD
1400
NWEAVTRTGA
1410
TEHYLINVCK
1420
SLAPQAGSEP
1430
CPPEAAVCLL
1440
GGAKPVNLGR
1450
VRDGPQWKDG
1460
ATLLKYVDGD
1470
PCPDRIRKKS
1480
TTIRFACRES
1490
QVSSRPMFIS
1500
AVEDCEYTFS
1510
WPTAAACPVK
1520
SNVHDNCQVT
1530
NPVTGHLFDL
1540
SSLSGRAGYT
1550
AAYSEKGLVY
1560
ISVCGDNENC
1570
APGVGACFGQ
1580
TRISVGKANK
1590
RLTYEDQVLR
1600
LVYKNGSPCP
1610
SKTGLTYTSV
1620
ISFVCRPEAG
1630
PTDKPVLISL
1640
DKQTCTLFFS
1650
WHTPLACEQE
1660
VECTVRNGSS
1670
IIDLSPLIHR
1680
TGGYEAFDES
1690
EDAASDTNPD
1700
FYINICQPLN
1710
PMHGVPCPAG
1720
AAVCKVPVDG
1730
APIDIGRVTG
1740
PPILNPIANE
1750
VYLNFESSTP
1760
CLADKHFNYT
1770
SLIAFHCKRG
1780
VSMGTPKLLR
1790
TSDCDFVFEW
1800
ETPLVCPDEV
1810
TTEGCSLTDE
1820
QLSYSFNLSS
1830
LSKSTFKVTR
1840
DSRTYSVGVC
1850
TAAAGLDQGG
1860
CKDGGVCLLS
1870
GSRGASFGRL
1880
ASMKLDYRHQ
1890
DEAVILSYAN
1900
GDNCPPETEE
1910
GDPCVFPFTL
1920
NGKSYEECVL
1930
EGRARLWCAT
1940
TADYDRDHEW
1950
GFCRHSNSHR
1960
TSAIIFKCDE
1970
DADVGRPQVF
1980
SEVRGCEVTF
1990
EWKTKVVCPP
2000
KKMECKFVQK
2010
HRTYDLRLLS
2020
SLTGSWFFVH
2030
DGASYYLNLC
2040
QRIYKGPLDC
2050
SDRASVCKKN
2060
PSGNVQVLGL
2070
VHTQKLDVIG
2080
DRVVVTYSKG
2090
HQCGGNKTAS
2100
TVIELTCAKT
2110
VGRPSFSRFD
2120
VDSCTYHVRW
2130
DSRAACAVKP
2140
QEVHMVNGTF
2150
TNPASGQSFS
2160
LGDIYFKRFS
2170
ASGDMRANGD
2180
KYLYEIQLSS
2190
ITSATHPACA
2200
GANICQVKPN
2210
DQHFSRKVGT
2220
SDKTKYYIQD
2230
GDLDVVFASS
2240
SKCGKDKTKS
2250
VSSTIFFHCD
2260
PLVKDGSPEF
2270
SHETADCQYL
2280
FSWYTSAVCP
2290
LEAGFGKNTG
2300
DDEPEHKGLS
2310
ERSQAVGAIL
2320
SLLLVALTGC
2330
LLTLLLYKKE
2340
RREAVMSRLT
2350
SCCRRGASVS
2360
YKYSKVNKEE
2370
EADENETEWL
2380
MEEIQLPTPR
2390
PGKEAQENGH
2400
ITTKSVKAEA
2410
LSSLRGDDQD
2420
SEDEVLTIPE
2430
VKVHPGRGPG
2440
DEGAHPMRPP
2450
QRQVLRERAD
2460
DRVGLVLEEP
2470
ARRGRPRAAH
2480
NKAVNSFHDD
SDEDLLHI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0030139 |
endocytic vesicle |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0005770 |
late endosome |
| Cellular Component |
GO:0005641 |
nuclear envelope lumen |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Cellular Component |
GO:0030140 |
trans-Golgi network transport vesicle |
| Molecular Function |
GO:0005537 |
D-mannose binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005520 |
insulin-like growth factor binding |
| Molecular Function |
GO:0051219 |
phosphoprotein binding |
| Molecular Function |
GO:1905394 |
retromer complex binding |
| Molecular Function |
GO:0038023 |
signaling receptor activity |
| Biological Process |
GO:0044794 |
host-mediated activation of viral process |
| Biological Process |
GO:0006622 |
protein targeting to lysosome |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.