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Overview

Uniprot IDF1SB67
Protein NameCation-independent mannose-6-phosphate receptor
Gene NameIGF2R
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1231 EGDNCSVKDPRHGNL
1265 YYFRVCGKLSSDVCP
1278 CPTSDRSKVISSCQE
170 KDIFKAKKEVPCYVF
1827 SLSKSTFKVTRDSRT
1985 VTFEWKTKVVCPPKK
2049 DRASVCKKNPSGNVQ
303 TLPKLTAKSNCRYEV
385 DAAVCQVKKADSTQA

Function

Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4

Protein Sequence

10 MGAAAGRSAH 20 LGPAPAGYRL 30 RSLLLVQLLL 40 LVWAPRATGT 50 QGTEFPELCS 60 YTWEAVDTKN 70 NRLYKISICG 80 NVAVAPCGTS 90 SAVCMQDLKT 100 NSFHSVGDSV 110 LKSASRSLLE 120 FNTTVSCGQQ 130 SANHRIQSSI 140 TFLCGKTLGT 150 PEFVTATDCV 160 HYFEWRTTAA 170 CKKDIFKAKK 180 EVPCYVFDRE 190 LKKRDLNPLI 200 KVGGAYLVDD 210 SDPDASLFIN 220 VCRDIDTLRD 230 RAPQLRACPL 240 GTAACLVRGD 250 WAFDVGRPRE 260 GLQLLSNDRL 270 VLSYVNEEPA 280 PPDFCDGHSP 290 AVTITFVCPS 300 ERREGTLPKL 310 TAKSNCRYEV 320 EWVTEYACPR 330 DYLESRNCFL 340 SSEQHDITID 350 LQPLSRVGDA 360 PYTCEGEEYV 370 FSLSVCGGAE 380 TPVCNEKDAA 390 VCQVKKADST 400 QAKVAGRLQN 410 QTLRYSDGDL 420 TLIYFGGDEC 430 SSGFQRMSVI 440 NFECNKTAGN 450 NGKGAPVFTG 460 EVDCTYFFTW 470 DTRYACVEEK 480 EALLCGVADG 490 RQRFDLSALA 500 RHSELEQNWE 510 AVDGSQRGAE 520 KKHFFINICR 530 RVLQEGQARG 540 CPEDAAACAV 550 DESGSKNLGK 560 FISSPTREKG 570 NIQLSYSDGD 580 ECGGGKRINT 590 NITLICKPGD 600 LESAPVLRTS 610 RADGCFYEFE 620 WYTAAACVLS 630 RTEGDNCTVF 640 DAQAGFSFDL 650 SPLTKTNGAY 660 KVETEKYEFY 670 INVCGAVSAS 680 ACQPDSGACQ 690 VSKSDKKSWN 700 LGRSNAKLSY 710 YDGMIQLNYH 720 DGTPYNNERR 730 TPRATLITFL 740 CDRDAGVGLP 750 EYQEEDNSTY 760 NFRWYTSYAC 770 PEEPLECVVT 780 DPSTLEQYDL 790 SSLAKSEGGR 800 GGNWYALDSA 810 GPHSTWRKYY 820 INVCRPLNPV 830 PGCDRYASAC 840 QMKYESHQGS 850 FSETVSISNL 860 GVAKAGPVVE 870 NSGSLVLEYV 880 NGSACTTSDG 890 RRTTYTTRIH 900 LVCSRGSLNT 910 HPIFSLSWEC 920 VVSFLWNTEA 930 ACPVRVTTDT 940 DQACSIRDPN 950 SGYVFDLNPL 960 NRSQGYVLTG 970 IGKTFVFNVC 980 GTMPICGTLD 990 GKLASGCEAE 1000 TETKELKNLR 1010 PGRLVGLEKI 1020 LQLSPEGFIT 1030 LTYTGLPSHP 1040 KGPADAFIIR 1050 FVCNGDLYPG 1060 VPKFLHRDID 1070 SRLGIWNTFF 1080 DFETALACVP 1090 SPVDCLVTDP 1100 EGNEYDLSGL 1110 SRVKKPWTAV 1120 DTTSDGKKRT 1130 FYLSVCNPLP 1140 YIPGCHGSMV 1150 GSCLVSEDKS 1160 LNLGVVQVSP 1170 QVAANGSLSV 1180 VYVNGDTCKD 1190 QRYSTRVILE 1200 CAHTAGSPTF 1210 QLLDDCEYVF 1220 VWRTVEACPV 1230 VRVEGDNCSV 1240 KDPRHGNLYD 1250 LKPLALNDTV 1260 VSAGEYTYYF 1270 RVCGKLSSDV 1280 CPTSDRSKVI 1290 SSCQEKRGPQ 1300 GFQKVAGLLT 1310 QKLTYENGVL 1320 KMNYTGGDTC 1330 HKVYQRSTTI 1340 FFYCDRSTQA 1350 PVFLQETSDC 1360 SYLFEWRTQY 1370 ACPPFDLTEC 1380 SFKDAAGNTF 1390 DLSSLARYSD 1400 NWEAVTRTGA 1410 TEHYLINVCK 1420 SLAPQAGSEP 1430 CPPEAAVCLL 1440 GGAKPVNLGR 1450 VRDGPQWKDG 1460 ATLLKYVDGD 1470 PCPDRIRKKS 1480 TTIRFACRES 1490 QVSSRPMFIS 1500 AVEDCEYTFS 1510 WPTAAACPVK 1520 SNVHDNCQVT 1530 NPVTGHLFDL 1540 SSLSGRAGYT 1550 AAYSEKGLVY 1560 ISVCGDNENC 1570 APGVGACFGQ 1580 TRISVGKANK 1590 RLTYEDQVLR 1600 LVYKNGSPCP 1610 SKTGLTYTSV 1620 ISFVCRPEAG 1630 PTDKPVLISL 1640 DKQTCTLFFS 1650 WHTPLACEQE 1660 VECTVRNGSS 1670 IIDLSPLIHR 1680 TGGYEAFDES 1690 EDAASDTNPD 1700 FYINICQPLN 1710 PMHGVPCPAG 1720 AAVCKVPVDG 1730 APIDIGRVTG 1740 PPILNPIANE 1750 VYLNFESSTP 1760 CLADKHFNYT 1770 SLIAFHCKRG 1780 VSMGTPKLLR 1790 TSDCDFVFEW 1800 ETPLVCPDEV 1810 TTEGCSLTDE 1820 QLSYSFNLSS 1830 LSKSTFKVTR 1840 DSRTYSVGVC 1850 TAAAGLDQGG 1860 CKDGGVCLLS 1870 GSRGASFGRL 1880 ASMKLDYRHQ 1890 DEAVILSYAN 1900 GDNCPPETEE 1910 GDPCVFPFTL 1920 NGKSYEECVL 1930 EGRARLWCAT 1940 TADYDRDHEW 1950 GFCRHSNSHR 1960 TSAIIFKCDE 1970 DADVGRPQVF 1980 SEVRGCEVTF 1990 EWKTKVVCPP 2000 KKMECKFVQK 2010 HRTYDLRLLS 2020 SLTGSWFFVH 2030 DGASYYLNLC 2040 QRIYKGPLDC 2050 SDRASVCKKN 2060 PSGNVQVLGL 2070 VHTQKLDVIG 2080 DRVVVTYSKG 2090 HQCGGNKTAS 2100 TVIELTCAKT 2110 VGRPSFSRFD 2120 VDSCTYHVRW 2130 DSRAACAVKP 2140 QEVHMVNGTF 2150 TNPASGQSFS 2160 LGDIYFKRFS 2170 ASGDMRANGD 2180 KYLYEIQLSS 2190 ITSATHPACA 2200 GANICQVKPN 2210 DQHFSRKVGT 2220 SDKTKYYIQD 2230 GDLDVVFASS 2240 SKCGKDKTKS 2250 VSSTIFFHCD 2260 PLVKDGSPEF 2270 SHETADCQYL 2280 FSWYTSAVCP 2290 LEAGFGKNTG 2300 DDEPEHKGLS 2310 ERSQAVGAIL 2320 SLLLVALTGC 2330 LLTLLLYKKE 2340 RREAVMSRLT 2350 SCCRRGASVS 2360 YKYSKVNKEE 2370 EADENETEWL 2380 MEEIQLPTPR 2390 PGKEAQENGH 2400 ITTKSVKAEA 2410 LSSLRGDDQD 2420 SEDEVLTIPE 2430 VKVHPGRGPG 2440 DEGAHPMRPP 2450 QRQVLRERAD 2460 DRVGLVLEEP 2470 ARRGRPRAAH 2480 NKAVNSFHDD SDEDLLHI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005769 early endosome
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005770 late endosome
Cellular Component GO:0005641 nuclear envelope lumen
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005802 trans-Golgi network
Cellular Component GO:0030140 trans-Golgi network transport vesicle
Molecular Function GO:0005537 D-mannose binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005520 insulin-like growth factor binding
Molecular Function GO:0051219 phosphoprotein binding
Molecular Function GO:1905394 retromer complex binding
Molecular Function GO:0038023 signaling receptor activity
Biological Process GO:0044794 host-mediated activation of viral process
Biological Process GO:0006622 protein targeting to lysosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.