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Overview

Uniprot ID	F1SB86
Protein Name	Tyrosine-protein phosphatase non-receptor type 12
Gene Name	PTPN12
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
395	DLNRNYNKSTELTAK
449	RGHAIKIKSASASPC
460	ASPCITDKISKSQEL
552	DTHCQTKKTVSLTPS

Function

Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades

Protein Sequence

10 MKSPDHNGED 20 NFARDFMRLR 30 RLSTKYRTEK 40 IYPTATGEKE 50 ENVKKNRYKD 60 ILPFDHSRVK 70 LTLKTPSQDS 80 DYINANFIKG 90 VYGPKAYVAT 100 QGPLANTVID 110 FWRMIWEYNV 120 VIIVMACREF 130 EMGRKKCERY 140 WPLYGEDPIT 150 FAPFKISCEA 160 EQARTDYFIR 170 TLLLEFQNES 180 RRLYQFHYVN 190 WPDHDVPSSF 200 DSILDMISLM 210 RKYQEHEDVP 220 ICIHCSAGCG 230 RTGAICAIDY 240 TWNLLKAGKI 250 PEEFNVFNLI 260 QEMRTQRHSA 270 VQTKEQYELV 280 HRAIAQLFEK 290 QLQLYEIHGV 300 QKIPDGVNET 310 NTENMVSSID 320 PDKQDSPPPK 330 PPRTRSCLVE 340 GDAKEEILQP 350 PEPHPVPPIL 360 TPSPPSAFPT 370 VTTVWQDNDR 380 YHPKPVLHMV 390 SSEQHSTDLN 400 RNYNKSTELT 410 AKNESAVEQI 420 DKKLERNLSF 430 EIKKVPLQEG 440 PKSFDGNTLL 450 NRGHAIKIKS 460 ASASPCITDK 470 ISKSQELSSR 480 DLKVDDISQN 490 SCVDCSATQS 500 NKAPVILPEE 510 LQKNSDTPPR 520 PDRLPLDEKG 530 RVTWSLHGPE 540 NTPPMPDSSE 550 GKSSDTHCQT 560 KKTVSLTPSP 570 TTQVETRDLS 580 DHQNSSPLFR 590 APLSFTNPLH 600 SDDSDSDERN 610 SDGAVTKNKT 620 SVSTASATVS 630 AAASTENIST 640 RKVLPMSIAR 650 HDIAGTIHSG 660 AEKDVDVSED 670 SPPPLPERTP 680 ESFVLASEHN 690 TPVRSEWSEL 700 QNQEESEQKK 710 PEGLITSGSE 720 TCNHPAGGFH 730 TETCTECPPT 740 FSNKKDQISE 750 SPTEATEIGF 760 GNRCGKPKGP RDPPSEWT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.