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Overview

Uniprot IDF1SBT5
Protein NameTranscription initiation factor IIF subunit alpha
Gene NameGTF2F1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
407 TLRAAANKLEQGKRT
421 TSETPAAKRLRLDTG
444 TPQPQSGKSTPSSGD
83 REEARRKKYGIVLKE

Function

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation

Protein Sequence

10 MAALGPCSQN 20 VTEYVVRVPK 30 NTTKKYNIMA 40 FNAADKVNLA 50 TWNQARLERD 60 LSNKKIYQEE 70 EMPESGAGSE 80 FNRKLREEAR 90 RKKYGIVLKE 100 FRPEDQPWLL 110 RINGKAGRKF 120 KGIKKGGVTE 130 NTSYYIFTQC 140 PDGAFEAFPV 150 HNWYNFTPLA 160 RHRTLTAEEA 170 EEEWERRNKV 180 LNHFSIMQQR 190 RLKDQDQDEE 200 DEDKEKRGRK 210 KASELRIHDL 220 EDDLEMSSDD 230 SEASGEEGGR 240 APKAKKKAPP 250 SKGGRKKKKK 260 KGSDDEAFED 270 SDDGDFEGQE 280 VDYMSDGSSS 290 SQDELEGKPK 300 VTQQEEGPKG 310 VDEQSESSEE 320 SEEEKPPEED 330 KEEEEEKKVP 340 TPQEKKRRKD 350 SSEESDSSEE 360 SDIDSEASSA 370 LFMAKKKTPP 380 KRERKPSGGS 390 SRGNSRPGTP 400 STEPGSTSST 410 LRAAANKLEQ 420 GKRTSETPAA 430 KRLRLDTGSQ 440 SLSGKSTPQP 450 QSGKSTPSSG 460 DVQVTEDAVR 470 RYLTRKPMTT 480 KDLLKKFQTK 490 KTGLSSEQTV 500 NVLAQILKRL 510 NPERKMINDK MHFSLKE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005669 transcription factor TFIID complex
Cellular Component GO:0005674 transcription factor TFIIF complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0019211 phosphatase activator activity
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0016251 RNA polymerase II general transcription initiation factor activity
Molecular Function GO:0001096 TFIIF-class transcription factor complex binding
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0009615 response to virus
Biological Process GO:0006368 transcription elongation by RNA polymerase II
Biological Process GO:0006367 transcription initiation at RNA polymerase II promoter

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.