Search Results
Overview
| Uniprot ID | F1SBU0 |
|---|---|
| Protein Name | Ran-binding protein 3 |
| Gene Name | RANBP3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 212 | SEEENCEKKEQVAQQ |
| 213 | EEENCEKKEQVAQQA |
Function
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export
Protein Sequence
10
MGFISGLFFL
20
FNLLQTNVAL
30
FTKNTVLGGK
40
TPIFLFAEKP
50
AIAPPVFVFQ
60
KDKGQKRSAG
70
GSSPEGGEDS
80
DREDGNYCPP
90
VKRERTSSLT
100
QFPPSQSVSK
110
NNVFMPSTFC
120
EPSAGNSDSE
130
PGLPSQKPKE
140
QQRSVLRPAV
150
LQAPQPKALS
160
QTVPSTGTNG
170
VSVPADCTGA
180
VTLASPDNPA
190
RRSPSDEVPA
200
LEEKESQKNE
210
SSNTSEEENC
220
EKKEQVAQQA
230
FVFGQNLRDR
240
VKLLPTLTMC
250
VHMVYTGIHT
260
VLPCSSRHPT
270
FMAHLLFSLE
280
NSTNSADAAS
290
SKFIFGQNMS
300
ERVLSPPKLN
310
EVSSDANRET
320
IAAESGSESS
330
SQEATPEKES
340
LAESAAAYTK
350
ATARKCLLEK
360
VEVITGEEAE
370
SNVLQIQCKL
380
FVFDKTSQSW
390
VERGRGLLRL
400
NDMASTDDGT
410
LQSRLVMRTQ
420
GSLRLILNTK
430
LWAQMQIDKA
440
SEKSIRITAM
450
DTEDQGVKVF
460
LISASSKDTG
470
QLYAALHHRI
480
LALRSRVEQE
490
QEAKTPAPEP
500
GAAPSNEDDS
510
DDDDVLAPSG
520
ATGSGAGDEG
DGQTAGST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.