Search Results
Overview
| Uniprot ID | F1SC53 |
|---|---|
| Protein Name | Nuclear receptor coactivator 5 |
| Gene Name | NCOA5 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | MDDYCRRKDDSYFDR |
Function
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2)
Protein Sequence
10
MNTAPSRPSP
20
TRRDPYGFGD
30
SRDTRRDRSP
40
IRGSPRREPR
50
DGRNGRDARD
60
SRDMRDMRDM
70
RDPRDLRDHR
80
DSRDMRDHRD
90
SRSMRDARDL
100
RDLRDFRDLR
110
DSRDFRDHRD
120
PMYDRYRDMR
130
DSRDPMYRRE
140
GSYDRYLRMD
150
DYCRRKDDSY
160
FDRYRDSFDG
170
RGPPGPENQS
180
RAKERLKREE
190
RRREELYRQY
200
FEEIQRRFDA
210
ERPVDCSVIV
220
VNKQTKDYAE
230
SVGRKVRDLG
240
MVVDLIFLNT
250
EVSLSQALED
260
VSRGGSPFAI
270
VITQQHQIHR
280
SCTVNIMFGT
290
PQEHRNMPQA
300
DAMVLVARNY
310
ERYKNECREK
320
EREEIARQAA
330
KMADEAILQE
340
RERGGPDEGM
350
RGGHPPAIQS
360
LINLLADNRY
370
LTAEETDKII
380
NYLRERKERL
390
MRSSTDSLPG
400
PISRQPLGAS
410
SGASLKTQPS
420
SQPLQSGQVL
430
PSATPTPAAA
440
PTSQQELQAK
450
ILSLFNSGTV
460
AANSSSASPS
470
VAAGNTQNQN
480
FSTAANSQPQ
490
QRSQASGNQP
500
PNILGQAGSA
510
RNMGPRPGAP
520
SQGLFGQPST
530
RLAPASNLAS
540
QRPVSSTAIN
550
FDNPSVQKAL
560
DTLIQSGPAL
570
SHLVSQTTAQ
580
VGRPQAPMGS
YQRHY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003682 | chromatin binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0009966 | regulation of signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.