Search Results

Overview

Uniprot IDF1SC98
Protein NameInsulin-degrading enzyme
Gene NameIDE
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
308 LYKIVPIKDIRNLYV
353 LLSELKSKGWVNTLV
483 VRVAIVSKSFEGKTD
637 SVKGYNDKQPILLKK
899 RRLDKPKKLSAECAK
938 LTKEDIIKFYKEMLA

Function

No function data available.

Protein Sequence

10 MRYRLAWLLH 20 PALPSTFRSV 30 LGARLPPLER 40 LCGFQKKTYS 50 KMNNSAIKRL 60 GNHIIKSPED 70 KREYRGLELA 80 NGIKVLLISD 90 PTTDKSSAAL 100 DVHIGSLSDP 110 PNIAGLSHFC 120 EHMLFLGTKK 130 YPKENEYSQF 140 LSEHAGSSNA 150 FTSGEHTNYY 160 FDVSHEHLEG 170 ALDRFAQFFL 180 CPLFDESCKD 190 REVNAVDSEH 200 EKNVMNDAWR 210 LFQLEKATGN 220 PNHPFSKFGT 230 GNKYTLETRP 240 NQEGIDVRQE 250 LLKFHSTYYS 260 SNLMAICVLG 270 RESLDDLTNL 280 VVKLFSEVEN 290 KNVPLPEFPE 300 HPFQEEHLRQ 310 LYKIVPIKDI 320 RNLYVTFPIP 330 DLQKYYKSNP 340 GHYLGHLIGH 350 EGPGSLLSEL 360 KSKGWVNTLV 370 GGQKEGARGF 380 MFFIINVDLT 390 EEGLLHVEDI 400 ILHMFQYIQK 410 LRAEGPQEWV 420 FQECKDLNAV 430 AFRFKDKERP 440 RGYTSKIAGI 450 LHYYPLEEVL 460 TAEYLLEEFR 470 PDLIEMVLDK 480 LRPENVRVAI 490 VSKSFEGKTD 500 RTEEWYGTQY 510 KQEAIPDEVI 520 KKWQNADLNG 530 KFKLPTKNEF 540 IPTNFEILSL 550 EKEATPYPSL 560 IKDTAMSKLW 570 FKQDDKFFLP 580 KACLNFEFFS 590 PFAYVDPLHC 600 NMAYLYLELL 610 KDSLNEYAYA 620 AELAGLSYDL 630 QNTIYGMYLS 640 VKGYNDKQPI 650 LLKKIIEKMA 660 TFEIDEKRFE 670 IIKEAYMRSL 680 NNFRAEQPHQ 690 HAMYYLRLLM 700 TEVAWTKDEL 710 KEALDDVTLP 720 RLKAFIPQLL 730 SRLHIEALLH 740 GNITKQAALG 750 IMQMVEDTLI 760 EHAHTKPLLP 770 SQLVRYREVQ 780 LPDRGWFVYQ 790 QRNEVHNNCG 800 IEIYYQTDMQ 810 STSENMFLEL 820 FCQIISEPCF 830 NTLRTKEQLG 840 YIVFSGPRRA 850 NGIQGLRFII 860 QSEKPPHYLE 870 SRVEAFLVTM 880 EKSIEDMAEE 890 AFQKHIQALA 900 IRRLDKPKKL 910 SAECAKYWGE 920 IISQQYNFDR 930 DNIEVAYLKT 940 LTKEDIIKFY 950 KEMLAVDAPR 960 RHKVSVHVLA 970 REMDSCPVVG 980 EFPCQNDINL 990 SQAPALPQPE 1000 VIQNMTEFKR 1010 GLPLFPLVKP HINFMAAKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0043559 insulin binding
Molecular Function GO:0004222 metalloendopeptidase activity
Molecular Function GO:0042277 peptide binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0150094 amyloid-beta clearance by cellular catabolic process
Biological Process GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
Biological Process GO:0010815 bradykinin catabolic process
Biological Process GO:0042447 hormone catabolic process
Biological Process GO:1901143 insulin catabolic process
Biological Process GO:0043171 peptide catabolic process
Biological Process GO:0051603 proteolysis involved in protein catabolic process
Biological Process GO:1903715 regulation of aerobic respiration
Biological Process GO:0010992 ubiquitin recycling

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.