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Overview

Uniprot IDF1SCG7
Protein NameATP-dependent RNA helicase
Gene NameDDX24
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
527 VETLTETKIHCETDE

Function

ATP-dependent RNA helicase that plays a role in various aspects of RNA metabolism including pre-mRNA splicing and is thereby involved in different biological processes such as cell cycle regulation or innate immunity. Plays an inhibitory role in TP53 transcriptional activity and subsequently in TP53 controlled cell growth arrest and senescence by inhibiting its EP300 mediated acetylation. Negatively regulates cytosolic RNA-mediated innate immune signaling at least in part by affecting RIPK1/IRF7 interactions. Alternatively, possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation. Plays an essential role in cell cycle regulation in vascular smooth muscle cells by interacting with and regulating FANCA (Fanconi anemia complementation group A) mRNA

Protein Sequence

10 MFADGQMDDL 20 VCFEELTDYR 30 LVSPAKNSSS 40 LFLKEESKKR 50 KAQAVAEGEE 60 EGESSSSKKK 70 MKLKKSRDVA 80 AEGTSVQKEF 90 GVKDPEPEPQ 100 GDSTVCPDAE 110 VGEMASESPA 120 QTVPKKKKKK 130 GKKKAEPSQG 140 TTPKVSKRAK 150 TWMPETHDHK 160 ADVSAWKDLF 170 VPKPVLRALS 180 FLGFSAPTPI 190 QALTLAPAIR 200 DKLDILGAAE 210 TGSGKTLAFA 220 IPMIHAVLQW 230 QVKKKPTPVL 240 STTGAPPEET 250 STEPGAEIGS 260 PGRAGTESGA 270 LPDKIGIDSE 280 ALPSEAGAKT 290 SATTADQVLP 300 SHDADDAGEG 310 PSSLIREKPV 320 PKQDENKEEK 330 LDEEHSGELK 340 QELNSKIATS 350 EAHPKRPLLG 360 LVLTPTRELA 370 VQVKQHIDAV 380 AKFTGIKTAI 390 LVGGMSTQKQ 400 QRMLNRQPEI 410 VIATPGRLWE 420 LVKEKQPHLS 430 NLRQLRCLVI 440 DEADRMVEKG 450 HFAELSQLLE 460 MLNDSQYNPK 470 RQTLVFSATL 480 TLVHQAPARI 490 LHKKHAKKID 500 KTAKLDLLMQ 510 KIGMRGKPKV 520 IDLTRNEATV 530 ETLTETKIHC 540 ETDEKDLYLY 550 YFLMQYPGRT 560 LVFANSISCI 570 KRLSGLLKVL 580 DIMPLTLHAC 590 MHQKQRLRNL 600 EQFAHLEDCV 610 LLATDVAARG 620 LDIPKVQHVI 630 HYQVPRTSEI 640 YVHRSGRTAR 650 ATNEGLSLML 660 VGPEDVINFK 670 KIYKTLKKDE 680 DIPLFPVQTK 690 YMDAVKERIR 700 LARQIEKAEY 710 RNFQACLHNS 720 WIEQAAAALE 730 IELEEEMYKG 740 GKVDQQEERR 750 RQKQMKILKK 760 ELRQLLAQPL 770 FKDDLKTKYP 780 TQSGQPPVLG 790 SAPRNAESAL 800 SCLSRQKKKR 810 KRRPKEQQQQ QPQPSTSAK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.