Search Results
Overview
| Uniprot ID | F1SDJ8 |
|---|---|
| Protein Name | Glutaredoxin-3 |
| Gene Name | GLRX3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | AHAPELTKKVQRHAS |
| 222 | IKELEASKELDTICP |
| 230 | ELDTICPKAPKLEER |
| 233 | TICPKAPKLEERLKV |
| 239 | PKLEERLKVLTNKAS |
Function
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity
Protein Sequence
10
MAAGAAEAAA
20
AVVEVGSAGQ
30
FEELLRLRAK
40
SLLVVHFWAP
50
WAPQCAQMND
60
VMAELAKEHP
70
QVSFVKLEAE
80
AVPEVSEKYG
90
ISSVPTFLFF
100
KNSQSIDRLD
110
GAHAPELTKK
120
VQRHASSSSF
130
PSGGSEHLKE
140
DLSLRLKKLT
150
HAAPCMLFMK
160
GTPQEPRCGF
170
SKQMVEILNK
180
HNIQFSSFDI
190
FSDEEVRQGL
200
KTYSNWPTYP
210
QLYVSGELIG
220
GLDIIKELEA
230
SKELDTICPK
240
APKLEERLKV
250
LTNKASVMLF
260
MKGNKQEAKC
270
GFSRQILEIL
280
NSTGFRNCAC
290
AHSLPAGIQS
300
YSHTRFQKMC
310
VDYETFDILE
320
DEEVRQGLKT
330
YSNWPTYPQL
340
YVKGELVGGL
350
DIVKELKENG
360
ELLPILKGEN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0046872 | metal ion binding |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051536 | iron-sulfur cluster binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.