Search Results
Overview
| Uniprot ID | F1SDX8 |
|---|---|
| Protein Name | Ribonuclease |
| Gene Name | RNASEH2A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 275 | KIKSYFSKSPRTHPC |
Function
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes
Protein Sequence
10
MDLSELERDN
20
TGRCRLNSPV
30
PAVCLKEPCV
40
LGVDEAGRGP
50
VLGPMVYAIC
60
YCPLSRLADL
70
EALKVADSKT
80
LSESERDRLF
90
AKMEEDGDFV
100
GWALDVLSPN
110
LISTSMLGRV
120
KYNLNSLSHD
130
TATGLVQYAL
140
DQGVKVAQVF
150
VDTVGLPETY
160
QERLQQRFPD
170
IEVTVKAKAD
180
ALYPVVSAAS
190
ICAKVARDQA
200
VRNWQFVEKL
210
QDLDTDYGSG
220
YPNDPKTKAW
230
LRKHVDPVFG
240
FPQFVRFSWR
250
TAQSILEKEA
260
EDVTWEDSQT
270
GDQEGLRKIK
280
SYFSKSPRTH
290
PCPHLSHRYF
300
QERGLESATT
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032299 | ribonuclease H2 complex |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0004523 | RNA-DNA hybrid ribonuclease activity |
| Biological Process | GO:0043137 | DNA replication, removal of RNA primer |
| Biological Process | GO:0006298 | mismatch repair |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.