Overview
| Uniprot ID | F1SED0 |
|---|
| Protein Name | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | ACADSB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 291 |
YAIQSLNKGRIGIAA |
Function
Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug
Protein Sequence
10
MEGSAGRLLR
20
GSALLRTNFP
30
TCLSSWKHPP
40
RVLKSSQPAP
50
LKTTNNGLSY
60
SPLQTFTDEE
70
MMIKNTVKKF
80
AQEQIAPLVS
90
KMDENSKMEK
100
SVIEGLFQQG
110
LMGIETEPKY
120
GGTGASFFSS
130
VLVIEELAKV
140
DASVALVCDL
150
QNTVINDLIG
160
RFGTEAQKAT
170
YLTKLATEQL
180
GSFCLSEPSA
190
GSDSFSLKTR
200
ADKDGDYYVI
210
NGSKMWITSA
220
EDAGLFLVMA
230
NVDPALGYKG
240
ITCFLVDRDT
250
EGLRVGKPEN
260
KLGIRASSTC
270
PVTLENAKVP
280
EANIVGQIGH
290
GYKYAIQSLN
300
KGRIGIAAQM
310
LGLAQGCFDL
320
TIPYLKERVQ
330
FGKRIFDFQG
340
LQHQVAHTAT
350
QLEAARLLTY
360
NAARLLEAGR
370
PFIKEASMAK
380
YYASEVAIQT
390
TNKCIEWMGA
400
VGYTKDYPME
410
KYFRDAKIGT
420
IYEGTSNIQL
430
NTIAKNVSKE
Y
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0003995 |
acyl-CoA dehydrogenase activity |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0003853 |
short-chain 2-methyl fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0046395 |
carboxylic acid catabolic process |
| Biological Process |
GO:0006631 |
fatty acid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.