Overview
| Uniprot ID | F1SF43 |
|---|
| Protein Name | Gap junction protein |
|---|
| Gene Name | GJA1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 136 |
QIEIKKFKYGIEEHG |
| 144 |
YGIEEHGKVKMRGGL |
| 258 |
TGPLSPSKDCGSPKY |
| 303 |
SSCRNYNKQASEQNW |
Function
Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response
Protein Sequence
10
MGDWSALGKL
20
LDKVQAYSTA
30
GGKVWLSVLF
40
IFRILLLGTA
50
VESAWGDEQS
60
AFRCNTQQPG
70
CENVCYDKSF
80
PISHVRFWVL
90
QIIFVSVPTL
100
LYLAHVFYVM
110
RKEEKLNKKE
120
EELKVAQTDG
130
VNVEMHLKQI
140
EIKKFKYGIE
150
EHGKVKMRGG
160
LLRTYIISIL
170
FKSVFEVAFL
180
LIQWYIYGFS
190
LSAVYTCKRD
200
PCPHQVDCFL
210
SRPTEKTIFI
220
IFMLVVSLVS
230
LALNIIELFY
240
VFFKGVKDRV
250
KGKSDPYHAT
260
TGPLSPSKDC
270
GSPKYAYFNG
280
CSSPTAPLSP
290
MSPPGYKLVT
300
GDRNNSSCRN
310
YNKQASEQNW
320
ANYSAEQNRM
330
GQAGSTISNS
340
HAQPFDFPDD
350
NQNSKKLDAG
360
HELQPLAIVD
370
QRPSSRASSR
380
ASSRPRPDDL
EI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005922 |
connexin complex |
| Cellular Component |
GO:0014704 |
intercalated disc |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0070160 |
tight junction |
| Molecular Function |
GO:0008013 |
beta-catenin binding |
| Molecular Function |
GO:0005243 |
gap junction channel activity |
| Molecular Function |
GO:1903763 |
gap junction channel activity involved in cell communication by electrical coupling |
| Molecular Function |
GO:0055077 |
gap junction hemi-channel activity |
| Molecular Function |
GO:0015075 |
monoatomic ion transmembrane transporter activity |
| Molecular Function |
GO:0015631 |
tubulin binding |
| Biological Process |
GO:0010644 |
cell communication by electrical coupling |
| Biological Process |
GO:0007267 |
cell-cell signaling |
| Biological Process |
GO:0000132 |
establishment of mitotic spindle orientation |
| Biological Process |
GO:0007507 |
heart development |
| Biological Process |
GO:0008104 |
intracellular protein localization |
| Biological Process |
GO:0032277 |
negative regulation of gonadotropin secretion |
| Biological Process |
GO:1901164 |
negative regulation of trophoblast cell migration |
| Biological Process |
GO:1905772 |
positive regulation of mesodermal cell differentiation |
| Biological Process |
GO:1905332 |
positive regulation of morphogenesis of an epithelium |
| Biological Process |
GO:2000648 |
positive regulation of stem cell proliferation |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.