Search Results
Overview
| Uniprot ID | F1SFI3 |
|---|---|
| Protein Name | Replication factor C subunit 4 |
| Gene Name | RFC4 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | KGTSISTKPPLTKDR |
| 18 | STKPPLTKDRGVAAT |
| 240 | VSEGDLRKAITFLQS |
| 255 | ATRLTGGKEVTEKMI |
| 331 | QKSVITEKLAEADKC |
Function
Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble
Protein Sequence
10
MQAFLKGTSI
20
STKPPLTKDR
30
GVAATARSSG
40
ENKKAKPVPW
50
VEKYRPKCVD
60
EVAFQEEVVA
70
VLKKSLEGAD
80
LPNLLFYGPP
90
GTGKTSTILA
100
AARELFGPEL
110
FRLRVLELNA
120
SDERGIQVVR
130
EKVKNFAQLT
140
VSGSRSDGKP
150
CPPFKIVILD
160
EADSMTSAAQ
170
AALRRTMEKE
180
SKTTRFCLIC
190
NYVSRIIEPL
200
TSRCSKFRFK
210
PLSDKIQQQR
220
LLDIADKEHV
230
KISDEGIAYL
240
VKVSEGDLRK
250
AITFLQSATR
260
LTGGKEVTEK
270
MITDIAGVVP
280
TETIDGVLAA
290
CQSGSFDKLE
300
AVVKDLIDEG
310
HAATQFVNQL
320
HDVVVENDNL
330
SDKQKSVITE
340
KLAEADKCLA
350
DGADEHLQLI
360
SLCATVMQQL
TQNC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031390 | Ctf18 RFC-like complex |
| Cellular Component | GO:0005663 | DNA replication factor C complex |
| Cellular Component | GO:0031391 | Elg1 RFC-like complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003689 | DNA clamp loader activity |
| Molecular Function | GO:0017116 | single-stranded DNA helicase activity |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006261 | DNA-templated DNA replication |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.