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Overview

Uniprot IDF1SFR1
Protein NamePrefoldin subunit 5
Gene NameMYG1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
100 EKTAEDAKDFFKRKI
106 AKDFFKRKIDFLTKQ
42 QLKVVQTKYVEAKDC
47 QTKYVEAKDCLNVLN
55 DCLNVLNKSNEGKEL

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC

Protein Sequence

10 MAQSVNITEL 20 NLPQLEMLKN 30 QLDQEVEFLS 40 TSIAQLKVVQ 50 TKYVEAKDCL 60 NVLNKSNEGK 70 ELLVPLTSSM 80 YVPGKLHDVE 90 HVLIDVGTGY 100 YVEKTAEDAK 110 DFFKRKIDFL 120 TKQMEKIQPA 130 LQEKHAMKQA 140 VMEMMSQKIQ 150 QLTALGAAQA TAKA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016272 prefoldin complex
Molecular Function GO:0001540 amyloid-beta binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:1905907 negative regulation of amyloid fibril formation
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0006457 protein folding
Biological Process GO:1990113 RNA polymerase I assembly
Biological Process GO:1990114 RNA polymerase II core complex assembly
Biological Process GO:1990115 RNA polymerase III assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.