Overview
| Uniprot ID | F1SFV7 |
|---|
| Protein Name | Protein S100 |
|---|
| Gene Name | S100A4 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 18 |
VMVSTFHKYSGKEGD |
| 22 |
TFHKYSGKEGDKFKL |
| 31 |
GDKFKLNKSELKELL |
| 35 |
KLNKSELKELLTREL |
| 48 |
ELPSFLGKRTDEAAF |
Function
Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors
Protein Sequence
10
MAYPLEKALD
20
VMVSTFHKYS
30
GKEGDKFKLN
40
KSELKELLTR
50
ELPSFLGKRT
60
DEAAFQKLMS
70
NLDSNRDNEV
80
DFQEYCVFLS
90
CIAMMCNEFF
100
EGFPDKQPRK
K
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0048306 |
calcium-dependent protein binding |
| Molecular Function |
GO:0042056 |
chemoattractant activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0050786 |
RAGE receptor binding |
| Molecular Function |
GO:0046914 |
transition metal ion binding |
| Biological Process |
GO:0043123 |
positive regulation of canonical NF-kappaB signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.