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Overview

Uniprot IDF1SGF1
Protein Name26S proteasome non-ATPase regulatory subunit 6
Gene NamePSMD6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
143 KANEDELKRLDEELE
178 YLCRIGDKEGALTAF
191 AFRKTYDKTVALGHR
226 TRNTEKAKSLIEEGG
345 VVEQEMKKDWLFAPH
410 RLHCKIDKVNEIVET
432 WQYQETIKKGDLLLN
433 QYQETIKKGDLLLNR

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MSSRGRCGRR 20 RTRDRKPGWR 30 RMRALTGSSH 40 FRRSCYLRGS 50 GLSFSLGRTC 60 AAAAAAAAAA 70 EMPLENLEEE 80 GLPKNPDLRI 90 AQLRFLLSLP 100 EHRGDAAVRE 110 ELMAAVRDNN 120 MAPYYEALCK 130 SLDWQMDVDL 140 LNKMKKANED 150 ELKRLDEELE 160 DAEKNLGESE 170 IRDAMMAKAE 180 YLCRIGDKEG 190 ALTAFRKTYD 200 KTVALGHRLD 210 IVFYLLRIGL 220 FYMDNDLITR 230 NTEKAKSLIE 240 EGGDWDRRNR 250 LKVYQGLYCV 260 AIRDFKQAAE 270 LFLDTVSTFT 280 SYELMDYKTF 290 VTYTVYVSMI 300 ALERPDLREK 310 VIKGAEILEV 320 LHSLPAVRQY 330 LFSLYECRYS 340 VFFQSLAVVE 350 QEMKKDWLFA 360 PHYRYYVREM 370 RIHAYSQLLE 380 SYRSLTLGYM 390 AEAFGVGVEF 400 IDQELSRFIA 410 AGRLHCKIDK 420 VNEIVETNRP 430 DSKNWQYQET 440 IKKGDLLLNR 450 VQKLSRVINM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005838 proteasome regulatory particle
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.