Search Results
Overview
| Uniprot ID | F1SGX1 |
|---|---|
| Protein Name | Chromatin assembly factor 1 subunit B |
| Gene Name | CHAF1B |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 286 | AHLPCPGKATLAVRC |
| 402 | PDTAKKTKSQTQSLP |
Function
Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer
Protein Sequence
10
MKVITCEIAW
20
HNKEPVYSLD
30
FQHGTAGRIH
40
RLASAGVDTT
50
VRIWKVEKGP
60
DGKAIVEFLS
70
NLARHTKAVN
80
VVRFSPNGEI
90
LASGGDDAVI
100
LLWKVNDNKE
110
PEQIAFQDED
120
EAQLNKENWT
130
VVKTLRGHLE
140
DVYDICWAAD
150
GNVMASASVD
160
NTAIIWDVSK
170
GQKISIFNEH
180
KSYVQGVTWD
190
PLGQYVATLS
200
CDRILRVYST
210
QKKRVAFNVS
220
KMLSGVGAEG
230
EARSYRMFHD
240
DSMKSFFRRL
250
SFTPDGSLLL
260
TPAGCVESGE
270
NVTNTTYVFS
280
RKNLKRPIAH
290
LPCPGKATLA
300
VRCCPVYFAL
310
RPAVEAGVEL
320
VSLPYRLVFA
330
VASEDSVLLY
340
DTQQLFPFGY
350
VSNIHYHTLS
360
DISWSSDGAF
370
LAISSTDGYC
380
SFVTFEKDEL
390
GIPLKEKPVL
400
SVRTPDTAKK
410
TKSQTQSLPG
420
PRLVEGTPTS
430
RAQDPSSPSA
440
TPPPGKQSLA
450
PAAAKDTPAA
460
TPAARGFWAA
470
PSEEKTLQAS
480
SQNVKGHPPR
490
RVTLNTLQAW
500
SKSTPRRINL
510
IPKTDSPPNS
520
IPTPLASSPS
530
TEEIQSEVPG
540
DPQGSPLELK
550
RPRLSEPKEG
QGLDP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0033186 | CAF-1 complex |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0006335 | DNA replication-dependent chromatin assembly |
| Biological Process | GO:0006334 | nucleosome assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.