Search Results
Overview
| Uniprot ID | F1SGZ8 |
|---|---|
| Protein Name | Twinfilin-1 |
| Gene Name | TWF1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 135 | DVSLHGYKKYLLSQS |
| 29 | NGKYRLLKISIENEK |
| 36 | KISIENEKLVIGSCR |
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles
Protein Sequence
10
MSHQTGIQAS
20
EDVKDIFARA
30
RNGKYRLLKI
40
SIENEKLVIG
50
SCRQPSDSWD
60
KDYDSFVLPM
70
LEDKQPCYIL
80
FRLDSQNAQG
90
YEWIFIAWSP
100
DHSHVRQKML
110
YAATRATLKK
120
EFGGGHIKDE
130
VFGTVKEDVS
140
LHGYKKYLLS
150
QSSPAPLTAA
160
EEELRQIKIN
170
EVQTDVSVDT
180
KHQTLQGVAF
190
PISREAFQAL
200
EKLNNRQLNY
210
VQLEIDIKNE
220
VIILANTVNT
230
ELKDLPKRIP
240
KDSARYHFFL
250
YKHSHEGDYL
260
ESIVFIYSMP
270
GYTCSIRERM
280
LYSSCKSPLL
290
EIVERQLQMD
300
VIRKIEIDNG
310
DELTADFLYE
320
EVHPKQHAHK
330
QSFAKPKGPS
340
GKRGIRRLIR
350
GPAETEATTD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0030837 | negative regulation of actin filament polymerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.