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Overview

Uniprot IDF1SH51
Protein NameStructural maintenance of chromosomes protein
Gene NameSMC4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1218 YKTYNITKSVAVNPK
207 SGKKKTFKDVGNLLR
268 GRLNEPIKVLCRRVE
501 PQTECELKEKEKELQ
543 AMNRSRGKVLDAIIQ
552 LDAIIQEKKTGRIPG
643 PRLFDLVKVKDEKIR
856 DKLDKINKQLDECAS
873 TKAQVAIKTADRNLK

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases

Protein Sequence

10 MPRKGTQPST 20 ARRREEGPPQ 30 SPDRTSSDAQ 40 PESPPGCSES 50 RAPATAETPS 60 EEIDNRSLEE 70 ILSSIPPPPP 80 PAMTNEAGAP 90 RLMITHIVNQ 100 NFKSYAGEKI 110 LGPFHKRFSC 120 IIGPNGSGKS 130 NVIDSMLFVF 140 GYRAQKIRSK 150 KLSVLIHNSD 160 EHKDIQSCTV 170 EVHFQKIIDK 180 EGNDYEVVPN 190 SNFYVSRTAY 200 RDNTSVYHIS 210 GKKKTFKDVG 220 NLLRSHGIDL 230 DHNRFLILQG 240 EVEQIAMMKP 250 KGQTEHDEGM 260 LEYLEDIIGS 270 GRLNEPIKVL 280 CRRVEILNEH 290 RGEKLNRVKM 300 VEKEKDALEG 310 EKNIAIEFLT 320 LENEIFRKKN 330 HVCQYYIYDL 340 QKRIAEMETQ 350 KEKIHEDTKE 360 INEKSNILSN 370 EMKAKNKAVK 380 DVEKKLNKIT 390 KFIEENKEKF 400 TKLDLEDVQV 410 REKLKHATSK 420 AKKLEKQLQK 430 DKEKSQEKEL 440 MGFSKSVNEA 450 RSKMDVAQSE 460 LDIYLSRYNT 470 AVSQLSKAKD 480 ALMAASETLK 490 ERKAAIGDIE 500 AKLPQTECEL 510 KEKEKELQKL 520 TQEEINFKSL 530 VRDLFQKVEE 540 AKSSLAMNRS 550 RGKVLDAIIQ 560 EKKTGRIPGI 570 YGRLGDLGAI 580 DEKYDVAISS 590 CCHALDYIVV 600 DSIDTAQECV 610 NFLKRQNIGV 620 ATFIGLDKMA 630 VWAKKMTQIQ 640 TPENTPRLFD 650 LVKVKDEKIR 660 QAFYFALRDT 670 LVADNLDQAT 680 RVAYQKDRRW 690 RVVTLQGQII 700 EQSGTMTGGG 710 SKVMKGRMGS 720 SVVVEISEEE 730 VNKMESQLQR 740 DSQKAVQIQE 750 HKVQLEETVV 760 KLRHSEREMR 770 NTLEKFTASI 780 QRLSEQEEYL 790 RVQVKELEAN 800 VLATAPDQKK 810 QKLLEENVNA 820 FKAEYDSVAE 830 KAGKVEAEVK 840 RLHNIIVEIN 850 NHKLKAQQDK 860 LDKINKQLDE 870 CASAITKAQV 880 AIKTADRNLK 890 KAQDSVFRTE 900 KEIKDTEKEV 910 DDLTTELKSL 920 EDKAAEVIKN 930 TNAAEESLPE 940 IQKEHRSLLQ 950 ELKVIQENEH 960 ALQKDALSIK 970 LKLEQIDGHI 980 GEHNSKIKYW 990 QKEISKISLH 1000 PIEDNPVEEI 1010 AVLTPEDLEA 1020 IKNPDSITNQ 1030 IALLEAQCHE 1040 MKPNLGAIVE 1050 YKKKEELYLQ 1060 RVAELDKITY 1070 ERDNFRQAYE 1080 DLRKQRLNEF 1090 MAGFYIITNK 1100 LKENYQMLTL 1110 GGDAELELVD 1120 SLDPFAEGIM 1130 FSVRPPKKSW 1140 KKIFNLSGGE 1150 KTLSSLALVF 1160 ALHHYKPTPL 1170 YFMDEIDAAL 1180 DFKNVSIVAF 1190 YIYEQTKNAQ 1200 FIIISLRNNM 1210 FEISDRLIGI 1220 YKTYNITKSV 1230 AVNPKEIASK GLC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000796 condensin complex
Cellular Component GO:0031981 nuclear lumen
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:0051301 cell division
Biological Process GO:0030261 chromosome condensation
Biological Process GO:0098813 nuclear chromosome segregation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.