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Overview

Uniprot IDF1SH94
Protein NameInter-alpha-trypsin inhibitor heavy chain H3
Gene NameITIH3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
122 DKTAGLVKASGRKLE
220 KKGHVSFKPSLDQQR

Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Protein Sequence

10 MASARWPCLI 20 LALLSSLAVS 30 GFPRSPSRQL 40 GVVNGIEVYS 50 TKVSCKVTSR 60 FAHNVVTTRA 70 VNHADTAKEV 80 SFDVELPKTA 90 FITNFTLTID 100 GVTYPGNVKE 110 KEVAKKQYEK 120 AVSQDKTAGL 130 VKASGRKLEK 140 FTVSVNVAAG 150 SKVTFELTYE 160 ELLKRHKGKY 170 EMYLKVQPKQ 180 LVKHFEITAD 190 IFEPQGISTL 200 DAEASFITND 210 LLGSALTKSF 220 SGKKGHVSFK 230 PSLDQQRSCP 240 TCTDSLLKGD 250 FIITYDVNRE 260 SPANVQIVNG 270 YFVHFFAPQG 280 LPVVPKNVVF 290 VIDVSGSMYG 300 RKMEQTKDAL 310 LKILDDIKED 320 DYLNFVLFSG 330 DVTTWKDSLV 340 QATPENIQKA 350 REFVRNIRDQ 360 GMTNINDGLL 370 TGISMLNKAR 380 EEHKVPERST 390 SIIIMLTDGD 400 ANMGVSKPEK 410 IQENVRNAIG 420 GKFPLYNLGF 430 GNNLNYNFLE 440 SMALENHGLA 450 RRIYEDSDAN 460 LQLQGFYEEV 470 ANPLLTSVEV 480 GYPENAIQDL 490 TQNTYQHFYD 500 GSEIVVAGRL 510 ADEDMNSFRA 520 DVKGHGAIND 530 LTFTEEVDMK 540 EMEEALKERD 550 YIFGNYIERL 560 WAYLTIEQLL 570 EKRKNAQGKE 580 KETLTAQALD 590 LSLKYHFVTP 600 LTSMVVTKPE 610 DNENQTAIAD 620 KPGEEPVDAV 630 TPSTAYLTSY 640 QPPVTPYYYV 650 DGDPHFIIQV 660 PEKDDAICFN 670 IDEDPGTVLR 680 LIQDPVTGLT 690 VNGQIIGEKR 700 SSQDSQPRKT 710 YFGKLGIANA 720 HLDFRIEVTP 730 ERITLWNGAA 740 QSTFSWLDTV 750 MVTQDGLSVM 760 INKKNMVVSF 770 GDGATFVVVL 780 HQVWKKQPNH 790 HDFLGFYVVD 800 SHRMSTQTHG 810 LLGQFFHPFD 820 FKVSDIHPGS 830 DPTKPDATMV 840 VKNHRLTVTR 850 GSQKDYRKDA 860 SIGVKVACWF 870 VHDNGQGLID 880 GIHSDYIVPD LF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005576 extracellular region
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0006953 acute-phase response
Biological Process GO:0030212 hyaluronan metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.