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Overview

Uniprot IDF1SHL3
Protein NameProtein transport protein SEC23
Gene NameSEC23A
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
193 SYVFRGTKDLSAKQL
318 RSWHDIEKDNAKYVK
329 KYVKKGTKHFEALAN
556 QLIRLCQKFGEYHKD
562 QKFGEYHKDDPSSFR

Function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules

Protein Sequence

10 MTTYLEFIQQ 20 NEERDGVRFS 30 WNVWPSSRLE 40 ATRMVVPVAA 50 LFTPLKERPD 60 LPPIQYEPVL 70 CSRTTCRAVL 80 NPLCQVDYRA 90 KLWACNFCYQ 100 RNQFPPTYAG 110 ISELNQPAEL 120 LPQFSSIEYV 130 VLRGPQMPLI 140 FLYVVDTCME 150 DEDLQALKES 160 MQMSLSLLPP 170 TALVGLITFG 180 RMVQVHELGC 190 EGISKSYVFR 200 GTKDLSAKQL 210 QEMLGLSKVP 220 VTQATRGPQV 230 QQPPPSNRFL 240 QPVQKIDMNL 250 TDLLGELQRD 260 PWPVPQGKRP 270 LRSSGVALSI 280 AVGLLECTFP 290 NTGARIMMFI 300 GGPATQGPGM 310 VVGDELKTPI 320 RSWHDIEKDN 330 AKYVKKGTKH 340 FEALANRAAT 350 TGHVIDIYAC 360 ALDQTGLLEM 370 KCCPNLTGGY 380 MVMGDSFNTS 390 LFKQTFQRVF 400 TKDMHGQFKM 410 GFGGTLEIKT 420 SREIKISGAI 430 GPCVSLNSKG 440 PCVSENEIGT 450 GGTCQWKICG 460 LSPTTTLAIY 470 FEVVNQHNAP 480 IPQGGRGAIQ 490 FVTQYQHSSG 500 QRRIRVTTIA 510 RNWADAQTQI 520 QNIAASFDQE 530 AAAILMARLA 540 IYRAETEEGP 550 DVLRWLDRQL 560 IRLCQKFGEY 570 HKDDPSSFRF 580 SETFSLYPQF 590 MFHLRRSPFL 600 QVFNNSPDES 610 SYYRHHFMRQ 620 DLTQSLIMIQ 630 PILYAYSFSG 640 PPEPVLLDSS 650 SILADRILLM 660 DTFFQILIYH 670 GETIAQWRKS 680 GYQDMPEYEN 690 FRHLLQAPVD 700 DAQEILHSRF 710 PMPRYIDTEH 720 GGSQARFLLS 730 KVNPSQTHNN 740 MYAWGQESGA 750 PILTDDVSLQ 760 VFMDHLKKLA VSSAA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030127 COPII vesicle coat
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070971 endoplasmic reticulum exit site
Cellular Component GO:0005789 endoplasmic reticulum membrane
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0090110 COPII-coated vesicle cargo loading
Biological Process GO:0006886 intracellular protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.