Search Results
Overview
| Uniprot ID | F1SI53 |
|---|---|
| Protein Name | Origin recognition complex subunit 2 |
| Gene Name | ORC2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 120 | ELAKTPRKSVSVNLK |
| 156 | VQLKSSDKSEFLSTA |
| 217 | QKTQAQNKVVSAPVC |
| 225 | VVSAPVCKETPSKKM |
| 48 | AQLLVNTKKIIKKPE |
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication
Protein Sequence
10
VMSKLELKEN
20
KMLEVQFVGD
30
DDVLNHILDR
40
EGGAKIKKER
50
AQLLVNTKKI
60
IKKPEYDVEE
70
DDQEVLKDQN
80
YVEVLGRDVQ
90
ESLKNGSATD
100
GGNKVYSFQN
110
RKHPEKMAKL
120
ASELAKTPRK
130
SVSVNLKSDP
140
EVMTDIPQCS
150
KGHSASDTVQ
160
LKSSDKSEFL
170
STAPRGLRKR
180
LIVPQSHSDS
190
ESEYSASNSE
200
EDEGLAQECE
210
EDTNEVILSQ
220
KTQAQNKVVS
230
APVCKETPSK
240
KMKRDKTSEL
250
VEEYFEAHSS
260
SKVLTSDRTL
270
QKLKRAKLDQ
280
QTLRNLLSKV
290
SPSFSAELKQ
300
LNQQYEQLFH
310
KWMLQLHLGF
320
NIVLYGLGSK
330
RDLLERFRTA
340
MLQDCIHVVI
350
NGFFPGISVK
360
SILNSITEEV
370
LDHMGTFRSV
380
LDQLDWIINK
390
FKEDSSLELF
400
LLIHNLDSQM
410
LRGDKSQQII
420
GQLSSLRNIY
430
LIASIDHLNA
440
PLMWDHAKQS
450
LYNWLWYETT
460
TYSPYTEETS
470
YENSLLVKQS
480
GSLPLSSLTH
490
VLRSLTPNAR
500
GIFRLLMKYQ
510
LENQDNPSYT
520
GLPFQDFYQQ
530
CREAFLVNSD
540
LTLRAQLTEF
550
RDHKLLRTKK
560
GGDGVEYLLI
570
PVDNGTLTDF
LAKEEEEV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0000939 | inner kinetochore |
| Cellular Component | GO:0005664 | nuclear origin of replication recognition complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003688 | DNA replication origin binding |
| Biological Process | GO:0006270 | DNA replication initiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.