Overview
| Uniprot ID | F1SI88 |
|---|
| Protein Name | Beta-hexosaminidase |
|---|
| Gene Name | HEXA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 369 |
EVFDNKVKVRPDTII |
Function
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A
Protein Sequence
10
MASRDSASWE
20
RRDRRSMAAS
30
TLWFSLLLAA
40
ASAGRATALW
50
PWPQYIKTSD
60
WSYTIVPHTF
70
QFQYHKSSAA
80
QVGCSVLDEA
90
FQRYRDLLFG
100
SVTLHFRHRV
110
EKWHISEKNS
120
LVVLVVTPGC
130
DQLPSLESVE
140
NYTLTINDEQ
150
CFLLSETVWG
160
ALRGLETFSQ
170
LIWKSPEGTF
180
YINRTEIEDF
190
PRFPHRGLLL
200
DTSRHYLPLA
210
SILDTLDVMA
220
YNKFNVFHWH
230
LVDDSSFPYE
240
SFTFPDLTKK
250
GSYNPSTHIY
260
TARDVKEVIE
270
YARLRGIRVL
280
AEFDTPGHTQ
290
SWGPGVPGLL
300
TPCYSGSQPS
310
GTFGPVNPTL
320
NYTYEFMSTF
330
FSEISSVFPD
340
FYLHLGGDEV
350
DFTCWLLGIV
360
SGYGKGYVVW
370
QEVFDNKVKV
380
RPDTIIQVWR
390
EEIPVKYMKE
400
MELVTLAGFR
410
ALLSAPWYLN
420
HITYGPDWKE
430
VYMVEPLAFE
440
GTPEQKALVI
450
GGEACMWGEY
460
VDSTNLVPRL
470
WPRAGAVAER
480
LWSNKAVTNL
490
DFAFKRLTHF
500
RCELLRRGVQ
510
AQPLSVGYCD
VEFEQT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005764 |
lysosome |
| Molecular Function |
GO:0004563 |
beta-N-acetylhexosaminidase activity |
| Biological Process |
GO:1901135 |
carbohydrate derivative metabolic process |
| Biological Process |
GO:0005975 |
carbohydrate metabolic process |
| Biological Process |
GO:0006629 |
lipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.