Search Results
Overview
| Uniprot ID | F1SIB1 |
|---|---|
| Protein Name | Prothrombin |
| Gene Name | F2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 600 | EGCDRDGKYGFYTHV |
Function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells
Protein Sequence
10
MAHVGGLWLP
20
GCLALAVLVS
30
LVHSQHVFMA
40
PQQALSLLQR
50
ARRANSGFFE
60
EMRKGNLERE
70
CVEEQCSREE
80
AYEALESPSE
90
TDAFWAKYTA
100
CESVRKSREK
110
LVECLEGNCA
120
EGLGMNYRGN
130
ISVTRSGIEC
140
QLWRSRYPHK
150
PEVNSTMYPG
160
ADLRENFCRN
170
PDGSITGPWC
180
YTTSPTVRRE
190
ACSIPVCGQG
200
RVTAELIPRS
210
GGSTVNVSPP
220
LETCVPERGR
230
QYQGRLAVTS
240
HGSPCLAWGS
250
SQAKALSKDQ
260
DFNPAVPLVE
270
NFCRNPDGDQ
280
EGAWCYVAGQ
290
PGDFEYCDLD
300
YCEEPVDEEV
310
GDALGENADA
320
AIEGRTTADD
330
FQPFFNEKTF
340
GAGEADCGLR
350
PLFEKSSLED
360
KTEKELFESY
370
IEGRIVEGSD
380
AEIGLAPWQV
390
MIFRKSPQEL
400
LCGASLISDR
410
WVLTAAHCLL
420
YPPWDKNFTE
430
NDLLVRIGKH
440
SRTRYERNIE
450
KISMLEKIYI
460
HPRYNWRENL
470
DRDIALLKLR
480
KPITFSDYIH
490
PVCLPDKETA
500
TKLLRAGYKG
510
RVTGWGNLKE
520
TWTTSASEVQ
530
PSVLQVVNLP
540
IVERLVCKAS
550
TRIRITDNMF
560
CAGYKPDEGK
570
RGDACEGDSG
580
GPFVMKSPFN
590
NRWYQMGIVS
600
WGEGCDRDGK
610
YGFYTHVFRL
620
KKWMQKVIDR
FGG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0001530 | lipopolysaccharide binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Molecular Function | GO:0070053 | thrombospondin receptor activity |
| Biological Process | GO:0006953 | acute-phase response |
| Biological Process | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0051838 | cytolysis by host of symbiont cells |
| Biological Process | GO:0042730 | fibrinolysis |
| Biological Process | GO:0048712 | negative regulation of astrocyte differentiation |
| Biological Process | GO:1900016 | negative regulation of cytokine production involved in inflammatory response |
| Biological Process | GO:0045861 | negative regulation of proteolysis |
| Biological Process | GO:0070945 | neutrophil-mediated killing of gram-negative bacterium |
| Biological Process | GO:0030168 | platelet activation |
| Biological Process | GO:0030194 | positive regulation of blood coagulation |
| Biological Process | GO:0032967 | positive regulation of collagen biosynthetic process |
| Biological Process | GO:1900738 | positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:1900182 | positive regulation of protein localization to nucleus |
| Biological Process | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0070493 | thrombin-activated receptor signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.