Search Results
Overview
| Uniprot ID | F1SIK9 |
|---|---|
| Protein Name | Septin |
| Gene Name | SEPTIN7 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | GPSHRIKKTVQVEQS |
| 124 | TVQVEQSKVLIKEGG |
| 213 | FMKRLHEKVNIIPLI |
| 235 | PEECQQFKKQIMKEI |
| 240 | QFKKQIMKEIQEHKI |
| 246 | MKEIQEHKIKIYEFP |
| 400 | KEKVQKLKDSEAELQ |
Function
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation
Protein Sequence
10
MNVTVENPQW
20
KLQQLTSWLS
30
RAGRGGGRGC
40
RSVRDPLLLR
50
RGASTAAPWQ
60
QKNLEGYVGF
70
ANLPNQVYRK
80
SVKRGFEFTL
90
MVVGESGLGK
100
STLINSLFLT
110
DLYSPEYPGP
120
SHRIKKTVQV
130
EQSKVLIKEG
140
GVQLLLTIVD
150
TPGFGDAVDN
160
SNCWQPVIDY
170
IDSKFEDYLN
180
AESRVNRRQM
190
PDNRVQCCLY
200
FIAPSGHGLK
210
PLDIEFMKRL
220
HEKVNIIPLI
230
AKADTLTPEE
240
CQQFKKQIMK
250
EIQEHKIKIY
260
EFPETDDEEE
270
NKLVKKIKDR
280
LPLAVVGSNT
290
IIEVNGKRVR
300
GRQYPWGVAE
310
VENGEHCDFT
320
ILRNMLIRTH
330
MQDLKDVTNN
340
VHYENYRSRK
350
LAAVTYNGVD
360
NNKNKGQLTK
370
SPLAQMEEER
380
REHVAKMKKM
390
EMEMEQVFEM
400
KVKEKVQKLK
410
DSEAELQRRH
420
EQMKKNLEAQ
430
HKELEEKRRQ
440
FEDEKANWEA
450
QQRILEQQNS
460
SRTLEKNKKK
GKIF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0032153 | cell division site |
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0097730 | non-motile cilium |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031105 | septin complex |
| Cellular Component | GO:0005940 | septin ring |
| Cellular Component | GO:0097227 | sperm annulus |
| Cellular Component | GO:0005819 | spindle |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Biological Process | GO:0007010 | cytoskeleton organization |
| Biological Process | GO:0061640 | cytoskeleton-dependent cytokinesis |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:1902857 | positive regulation of non-motile cilium assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.