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Overview

Uniprot IDF1SIM2
Protein NameAnillin
Gene NameANLN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
143 ATAASSVKTRMQKLA
148 SVKTRMQKLAEQRRH
299 KATSSPVKSSTTSVI
337 EASKPIEKSTVSRTV
347 VSRTVRPKEELNREV
361 VCLQSQSKDKATTPG
363 LQSQSKDKATTPGGT
430 THLAQQLKQERQKEL
446 CLRGRFDKGNLWSAE
461 KGENSRSKQLETKQE
477 PCQNTPLKKSQVNPN
478 CQNTPLKKSQVNPNT
535 LEEEKSLKVTSDPKV
650 DESPKPGKFQRTRVP
693 EIDRPSIKQVIVRKE
705 RKEDVTSKLDEKKNG
772 LLLIATEKRTLLIDE
784 IDELNKLKNEGPQRK
793 EGPQRKNKASPTSQS

Function

Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration

Protein Sequence

10 MDPFTEKLLE 20 RTRARRENLQ 30 RKMAERPIPA 40 ARSMTHAKRV 50 REPLSEASNQ 60 QPLSGGEEKS 70 CTKPSPSKKR 80 CSDNTEVEVS 90 NLENEKPIES 100 ASAKPCSPGT 110 VSPQAQPQAP 120 APASDSVAAP 130 ASLLGMRRGL 140 NSRLEATAAS 150 SVKTRMQKLA 160 EQRRHWDSDD 170 VTDDVPESSH 180 VSALPSEEKA 190 ASPPKPSLSA 200 ASATPVGRRG 210 RLADLAATIC 220 SWEDDVKNSS 230 AKQNSVQEQP 240 GTTCLSKFSS 250 ASGASAGINS 260 SSVKQEATCC 270 SQRDGDASLN 280 KASSSSAVGA 290 SLINGAISST 300 VKATSSPVKS 310 STTSVIGAKN 320 CEVQNPELLQ 330 KTPVSPLKTE 340 ASKPIEKSTV 350 SRTVRPKEEL 360 NREVCLQSQS 370 KDKATTPGGT 380 GIKPFLERFG 390 ERCQEHSKES 400 PARSTPHRTP 410 VITPNTKAIQ 420 ERLFKQNASS 430 STTHLAQQLK 440 QERQKELACL 450 RGRFDKGNLW 460 SAEKGENSRS 470 KQLETKQEIP 480 CQNTPLKKSQ 490 VNPNTPSLPG 500 TEKVTENQTP 510 TKTSSTEPTG 520 FSECEMMKSS 530 PLKITLFLEE 540 EKSLKVTSDP 550 KVEQQTEVVR 560 EIEMSVDDDD 570 DINSSKVIND 580 IFSDVLEEGE 590 LDVEKSQEEM 600 DQADADSSEE 610 QEDALNISSM 620 SLLAPLAQTV 630 GVVSPESLVS 640 SPRLELKDTS 650 VSDESPKPGK 660 FQRTRVPRAE 670 SGDSIGSEDR 680 DLPYSIDAYR 690 SQRVKEIDRP 700 SIKQVIVRKE 710 DVTSKLDEKK 720 NGFPCQVNIK 730 QKMQELNNEI 740 NLQQTVIYQA 750 SQALNCCVDE 760 EHGKGSLEEA 770 EAERLLLIAT 780 EKRTLLIDEL 790 NKLKNEGPQR 800 KNKASPTSQS 810 EFVPSKGSIT 820 LSEIRLPLKA 830 DFVCSTIQKP 840 DAANYYFLII 850 LKAGAENMVA 860 TPLASTSNSL 870 NGDALTFSTT 880 FTLQDVSNDF 890 EINIEVYSLV 900 QKKDPSGPDK 910 KKKAYKSKAI 920 TPKRLLTSIT 930 TKSTLPSSVM 940 ASLNAVRTSS 950 FALVGSYTLS 960 LSSVGNTKFA 970 LDKINYDLKE 980 RELLGYMFQE 990 KVPFLSPLEG 1000 HIYLKIKCQV 1010 NSSVEERGFL 1020 TIFEDVSGFG 1030 AWHRRWCVLS 1040 GNCISYWTYP 1050 DDEKRKNPIG 1060 RLNLANCTSR 1070 QIEPANREFC 1080 ARRNTFELIT 1090 VRPQREDDRE 1100 TLVSQCRDTL 1110 CVTKNWLSAD 1120 TKEERDLWMQ 1130 KLNQVLVDIR 1140 LWQPDACYKP IGKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005826 actomyosin contractile ring
Cellular Component GO:0032059 bleb
Cellular Component GO:0030496 midbody
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003779 actin binding
Biological Process GO:0000915 actomyosin contractile ring assembly
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0090521 podocyte cell migration
Biological Process GO:1904172 positive regulation of bleb assembly
Biological Process GO:0031106 septin ring organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.