Search Results
Overview
| Uniprot ID | F1SIU8 |
|---|---|
| Protein Name | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
| Gene Name | ILKAP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | GDVISVEKTVKRCLL |
| 228 | RYNEESQKHAALSLS |
| 277 | SIGDGQYKRCGVTSV |
| 351 | ACNRLATKAVQRGSA |
| 77 | LVEKKVCKASSAIFG |
Function
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation
Protein Sequence
10
MDLFGDLPEP
20
ERSPRPAAGS
30
GGPLLFDDLP
40
PASSGDAGSL
50
DASPSQTGKN
60
EGKGAKRKTS
70
EEEKNGSEEL
80
VEKKVCKASS
90
AIFGLKGYVA
100
ERKGEREEMQ
110
DAHVILNDIT
120
EECRPPSSLI
130
TRVSYFAVFD
140
GHGGIRASKF
150
AAQNLHQNLI
160
RKFPKGDVIS
170
VEKTVKRCLL
180
DTFKHTDEEF
190
LKQASSQKPA
200
WKDGSTATCV
210
LAVDNTLYIA
220
NLGDSRAILC
230
RYNEESQKHA
240
ALSLSKEHNP
250
TQYEERMRIQ
260
KAGGNVRDGR
270
VLGVLEVSRS
280
IGDGQYKRCG
290
VTSVPDIRRC
300
QLTPNDRFIL
310
LACDGLFKVF
320
TPEEAVHFIL
330
SCLEDEKIQS
340
REGKPAVDAR
350
YEAACNRLAT
360
KAVQRGSADN
370
VTVMVVRIGR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.