Overview
| Uniprot ID | F1SJ34 |
|---|
| Protein Name | Cytochrome c oxidase subunit 5A, mitochondrial |
|---|
| Gene Name | COX5A |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 115 |
VRILEVVKDKAGPHK |
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Protein Sequence
10
MLGAAVRRCS
20
VAAAAVARAS
30
PRGLLHPTPT
40
PGPAAAIQSI
50
RCYSHGSHET
60
DEEFDARWVT
70
YFNKPDIDAW
80
ELRKGMNTLV
90
GYDLVPEPKI
100
IDAALRACRR
110
LNDFASAVRI
120
LEVVKDKAGP
130
HKEIYPYVIQ
140
ELRPTLNELG
150
ISTPEELGLD
KV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045277 |
respiratory chain complex IV |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.