Search Results
Overview
| Uniprot ID | F1SJB5 |
|---|---|
| Protein Name | Annexin |
| Gene Name | ANXA1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 157 | REINRVYKEELKRDL |
| 166 | ELKRDLAKDITSDTS |
| 185 | KALLSLAKGDRSEDL |
| 250 | YSKHDMNKVLDLELK |
| 274 | VVKCATSKPMFFAEK |
| 287 | EKLHQAMKGIGTRHK |
| 29 | IKTVKGSKGGPGSAV |
| 312 | EIDMNDIKACYQKLY |
| 81 | NAQRQQIKAAYLQEK |
| 88 | KAAYLQEKGKPLDEA |
| 90 | AYLQEKGKPLDEALK |
| 97 | KPLDEALKKALTGHL |
Function
Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2
Protein Sequence
10
MAMVSEFLKQ
20
AWFIDNEEQE
30
YIKTVKGSKG
40
GPGSAVSPYP
50
TFNPSSDVEA
60
LHKAITVKGV
70
DEATIIEILT
80
KRTNAQRQQI
90
KAAYLQEKGK
100
PLDEALKKAL
110
TGHLEEVALA
120
LLKTPAQFDA
130
DELRAAMKGL
140
GTDEDTLNEI
150
LASRTNREIR
160
EINRVYKEEL
170
KRDLAKDITS
180
DTSGDYQKAL
190
LSLAKGDRSE
200
DLAINDDLAD
210
TDARALYEAG
220
ERRKGTDLNV
230
FITILTTRSY
240
PHLRRVFQKY
250
SKYSKHDMNK
260
VLDLELKGDI
270
ENCLTVVVKC
280
ATSKPMFFAE
290
KLHQAMKGIG
300
TRHKTLIRIM
310
VSRSEIDMND
320
IKACYQKLYG
330
ISLCQAILDE
340
TKGDYEKILV
ALCGGD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0031514 | motile cilium |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0001891 | phagocytic cup |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0019834 | phospholipase A2 inhibitor activity |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0046632 | alpha-beta T cell differentiation |
| Biological Process | GO:0071385 | cellular response to glucocorticoid stimulus |
| Biological Process | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| Biological Process | GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| Biological Process | GO:0071621 | granulocyte chemotaxis |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0030216 | keratinocyte differentiation |
| Biological Process | GO:0002548 | monocyte chemotaxis |
| Biological Process | GO:0014839 | myoblast migration involved in skeletal muscle regeneration |
| Biological Process | GO:0045920 | negative regulation of exocytosis |
| Biological Process | GO:0032717 | negative regulation of interleukin-8 production |
| Biological Process | GO:0045629 | negative regulation of T-helper 2 cell differentiation |
| Biological Process | GO:0042119 | neutrophil activation |
| Biological Process | GO:0097350 | neutrophil clearance |
| Biological Process | GO:0006909 | phagocytosis |
| Biological Process | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| Biological Process | GO:0032743 | positive regulation of interleukin-2 production |
| Biological Process | GO:0033031 | positive regulation of neutrophil apoptotic process |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0045627 | positive regulation of T-helper 1 cell differentiation |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
| Biological Process | GO:0090303 | positive regulation of wound healing |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0046883 | regulation of hormone secretion |
| Biological Process | GO:0050727 | regulation of inflammatory response |
| Biological Process | GO:0032652 | regulation of interleukin-1 production |
| Biological Process | GO:0002685 | regulation of leukocyte migration |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.