Search Results
Overview
| Uniprot ID | F1SJH8 |
|---|---|
| Protein Name | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
| Gene Name | ILKAP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | GDVISVEKTVKRCLL |
| 240 | RYNEESQKHAALSLS |
| 289 | SIGDGQYKRCGVTSV |
| 363 | ACNRLATKAVQRGSA |
| 89 | LVEKKVCKASSAIFG |
Function
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation
Protein Sequence
10
MTRVGVLVGW
20
ILRLEPRPGL
30
WIHPVFCCVS
40
GSGGPLLFDD
50
LPPASSGDAG
60
SLDASPSQTG
70
KNEGKGAKRK
80
TSEEEKNGSE
90
ELVEKKVCKA
100
SSAIFGLKGY
110
VAERKGEREE
120
MQDAHVILND
130
ITEECRPPSS
140
LITRVSYFAV
150
FDGHGGIRAS
160
KFAAQNLHQN
170
LIRKFPKGDV
180
ISVEKTVKRC
190
LLDTFKHTDE
200
EFLKQASSQK
210
PAWKDGSTAT
220
CVLAVDNTLY
230
IANLGDSRAI
240
LCRYNEESQK
250
HAALSLSKEH
260
NPTQYEERMR
270
IQKAGGNVRD
280
GRVLGVLEVS
290
RSIGDGQYKR
300
CGVTSVPDIR
310
RCQLTPNDRF
320
ILLACDGLFK
330
VFTPEEAVHF
340
ILSCLEDEKI
350
QSREGKPAVD
360
ARYEAACNRL
370
ATKAVQRGSA
380
DNVTVMVVRI
GR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.